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Oral Contraceptive Pill Treatment Alters Gene Expression of Inflammatory Markers in Polycystic Ovary Syndrome Women

research Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women

2 citations , February 2023 in “BMC women's health”

In this study, oral contraceptive use in women with PCOS increased the expression of certain inflammatory gene markers, which were positively associated with metabolic abnormalities.

research Metabolic and Vascular Inflammation in Alopecia Areata: Linking Uric Acid, Lipid Imbalance and ICAM ‐1 Upregulation

December 2025 in “Experimental Dermatology”

This study found that uric acid-linked microvascular dysfunction may play a role in alopecia areata, suggesting that targeting endothelial function and uric acid regulation could be a potential management strategy.

research Allogeneic Hair Transplantation with Enhanced Survival by Anti-ICAM-1 Antibody with Short-Term Rapamycin Treatment in Nonhuman Primates

4 citations , October 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that the MD-3 antibody significantly improved the survival of hair follicle allografts in nonhuman primates by reducing T-cell infiltration.

Serum Levels of VWF, t-PA, TNF-α, and ICAM-1 in Patients Receiving Hemocoagulase Combined with Platelet-Rich Plasma During Total Hip Replacement

research Serum Levels of VWF, t-PA, TNF-α, and ICAM-1 in Patients Receiving Hemocoagulase Combined with Platelet-Rich Plasma during Total Hip Replacement

2 citations , January 2022 in “Genetics Research”

This study found that using hemocoagulase combined with platelet-rich plasma during total hip replacement surgery led to reduced perioperative blood loss and improved early joint range of motion in osteoarthritis patients.

research Intercellular Adhesion Molecule-1 and Hair Follicle Regression

29 citations , April 2000 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

This study found that ICAM-1 expression in murine skin is developmentally regulated and crucial for skin and hair follicle remodeling beyond its recognized role in immune responses.

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community How the hell am I still losing hair

in Finasteride/Dutasteride 8 upvotes 11 months ago

The user has been experiencing sudden and aggressive hair shedding despite using oral dutasteride and topical minoxidil for six years, and recently added topical finasteride without improvement. Possible causes discussed include stress-related hair loss, dietary changes, or high DHT sensitivity, with suggestions to consult a doctor and consider adjusting treatments.

community Fin bad responder? My experience

3 upvotes 5 years ago

The user experienced side effects from ecklonia cava similar to those reported with finasteride, including depression, brain fog, anxiety, and testicular pain. Despite these issues, the user is still considering using topical finasteride in the future.

community Uncle not on meds vs. uncle on finasteride

in Progress Pictures 342 upvotes 1 year ago

A 43-year-old uncle on finasteride for 5 years has more hair than his 53-year-old uncle not on medication. Users discuss the effects and side effects of finasteride, including potential sexual side effects and gynecomastia.

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