Dynamic Expression Patterns of Tenascin, Proteoglycans, and Cell Adhesion Molecules During Human Hair Follicle Morphogenesis
February 1994
in “
Developmental dynamics
”
TLDR Specific proteins and molecules play key roles in the development of human hair follicles.
The study investigated the roles of tenascin, NCAM, E-cadherin, ICAM-1, CSPG, and perlecan in human hair follicle morphogenesis in fetal skin. Tenascin appeared at the epidermal-mesenchymal interface before hair follicle initiation and remained prominent in the follicle sheath. NCAM was initially widespread in the dermis but later localized to the dermal condensation and follicle sheath. E-cadherin was reduced on follicle cells near the basement membrane. ICAM-1 was transiently present during early follicle development. CSPG showed distinct patterns, with one epitope co-distributing with tenascin, another also found on follicle epithelial cells, and a third absent during follicle elongation. Perlecan was concentrated in the dermal papilla and all skin basement membranes. The study proposed a model for the interaction of these molecules in hair follicle development.
