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GlossaryBasement Membrane

thin layer separating epithelial cells from underlying connective tissue

The basement membrane is a thin, fibrous layer that lies between the epithelial cells (which line surfaces and cavities of organs) and the underlying connective tissue. It provides structural support, acts as a barrier to regulate the movement of cells and molecules, and plays a crucial role in tissue repair and regeneration. In the context of hair, the basement membrane surrounds hair follicles, helping to anchor them in place and maintain their structure.

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research Mapping the Molecular and Structural Specialization of the Skin Basement Membrane for Inter-Tissue Interactions

35 citations, May 2021 in “Nature communications”

The skin's basement membrane has specialized structures and molecules for different tissue interactions, important for hair growth and attachment.

research Mutations In AEC Syndrome Skin Reveal A Role For p63 In Basement Membrane Adhesion, Skin Barrier Integrity And Hair Follicle Biology

33 citations, February 2012 in “British Journal of Dermatology”

Mutations in the p63 gene affect skin adhesion, barrier integrity, and hair growth.

research Re-Investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis?

13 citations, June 2018 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

Laminin-511 may contribute to psoriasis by affecting skin cell growth and survival.

research Mapping the Molecular and Structural Specialization of the Skin Basement Membrane for Inter-Tissue Interactions

2 citations, April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The skin's basement membrane is specially designed to support different types of connections between skin layers and hair follicles.

research Regeneration of the Epidermis and Mucosal Epithelium on the Basement Membranes

2 citations, December 2003 in “Medical electron microscopy”

The skin and mucous membranes can regenerate over the basement membrane after damage, using nearby surviving cells.

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community "but it will hurt my gains bro"

in Satire 1302 upvotes 2 months ago

The conversation humorously discusses hair loss treatments like Minoxidil, Finasteride, and Dutasteride, and their effects on hair and muscle gains. Users debate effectiveness and side effects, mixing scientific approaches with jokes.

community RU58841, 8% HPLC-MS done by jano, they legit

in Research/Science 8 upvotes 3 years ago

The conversation is about testing the effectiveness of RU58841 for hair loss, with the user planning to increase their dose to 30 mg per day along with 20 mg of Minoxidil. The test results showed approximately 70 mg/ml, which the user considers a good result.

community Jason Sorgi Boston Hair Restoration- revived me from the ashes lol (5 months)

in Transplants 104 upvotes 8 months ago

A user is very satisfied with their hair transplant results, despite choosing a straight hairline against the doctor's advice for a more natural look. Some commenters think the hairline looks artificial, while others discuss the importance of a natural-looking hairline and inquire about any medications used post-transplant.

community This sub in a nutshell when it comes to medicine. Oral Minoxidil isn’t that bad

in Chat 446 upvotes 1 year ago

The post and conversation are about the use of oral Minoxidil (Min), Finasteride (Fin), and RU58841 for hair loss treatment, with mixed opinions on their safety and effectiveness.

community Starting Pyrilutamide BID. First dose was yesterday. Diffuse thinning. I will put my full regimen below.

in Research/Science 89 upvotes 2 years ago

A user's regimen to help with their diffuse thinning, which includes taking Pyrilutamide BID, 1mg finasteride daily, 2.5mg oral minoxidil daily, topical minoxidil since August 2021, LLLT every two days, topical fin, progesterone, melatonin, minoxidil (started one week ago), pumpkin seed oil and not dermarolling; other commenters suggested Nizoral for dandruff control and caution when using pre-mixed products with Pyrilutamide.

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