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GlossaryLaminin-332

protein crucial for skin's structural integrity and function

Laminin-332, also known as Laminin-5, is a protein crucial for the structural integrity and function of the skin. It is a key component of the basement membrane, which supports the attachment of the epidermis (outer skin layer) to the dermis (inner skin layer). Deficiencies or mutations in Laminin-332 can lead to skin disorders such as junctional epidermolysis bullosa, a condition characterized by fragile skin that blisters easily.

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research Spatial And Temporal Control Of Laminin-511 And -332 Expressions During Catagen

6 citations , April 2010 in “Journal of Dermatological Science”

Laminin-511 may help promote hair growth, while laminin-332 does not affect hair loss.

research Characterization of the Epidermal-Dermal Junction in hiPSC-Derived Skin Organoids

14 citations , May 2022 in “Stem cell reports”

The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.

research Laminin-511, Inducer of Hair Growth, Is Down-Regulated and Its Suppressor in Hair Growth, Laminin-332 Up-Regulated in Chemotherapy-Induced Alopecia

13 citations , April 2010 in “Journal of dermatological science”

Chemotherapy-induced hair loss is partly due to decreased laminin-511 and increased laminin-332.

A Case of Antilaminin 332 Mucous Membrane Pemphigoid Showing a Blister on the Bulbar Conjunctiva and a Unique Epitope on the α3 Subunit

research A Case of Antilaminin 332 Mucous Membrane Pemphigoid Showing a Blister on the Bulbar Conjunctiva and a Unique Epitope on the α3 Subunit

7 citations , February 2010 in “British Journal of Dermatology”

A woman with a rare autoimmune disorder had a blister on her eye and unique immune reaction, which was effectively treated with medication.

research Micropatterned Dermal–Epidermal Regeneration Matrices Create Functional Niches That Enhance Epidermal Morphogenesis

65 citations , August 2013 in “Acta Biomaterialia”

The new matrix improves skin regeneration and graft performance.

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community Summary of Procapil video by Haircafe

in Minoxidil 2 upvotes 8 months ago

Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.