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GlossaryHemidesmosomes

specialized structures anchoring cells to basement membranes

Hemidesmosomes are specialized structures that anchor cells to the underlying basement membrane, providing stability and support. They play a crucial role in maintaining the integrity of tissues, especially in areas subject to mechanical stress, such as the skin and hair follicles.

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research Wnt/β-Catenin Signaling Stabilizes Hemidesmosomes in Keratinocytes

5 citations, November 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Wnt/β-catenin signaling is important for keeping skin cell attachment structures stable.

SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes

research SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes

4 citations, December 2022 in “Advanced science”

SCD1 is important for hair growth by keeping the connection in skin cells where hair stem cells live stable.

research Co-Factors of LIM Domains (Clims/Ldb/Nli) Regulate Corneal Homeostasis and Maintenance of Hair Follicle Stem Cells

25 citations, December 2007 in “Developmental biology”

Clim proteins are essential for maintaining healthy corneas and hair follicles.

research Number Changes and Development Potential of Wool Follicle Cells in the Early Stages of Fiber Differentiation

22 citations, September 1982 in “Journal of ultrastructure research”

Wool follicle cells are more complex than previously thought.

research Characterization of the Epidermal-Dermal Junction in hiPSC-Derived Skin Organoids

14 citations, June 2022 in “Stem cell reports”

The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.

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