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GlossaryHemidesmosomes

specialized structures anchoring cells to basement membranes

Hemidesmosomes are specialized structures that anchor cells to the underlying basement membrane, providing stability and support. They play a crucial role in maintaining the integrity of tissues, especially in areas subject to mechanical stress, such as the skin and hair follicles.

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research Histological Changes of Pre and Postnatal Skin Development in Rats

January 2012

Rat skin develops from a single layer to adult-like skin with hair follicles by day 21.

research Characterization of the Epidermal-Dermal Junction in hiPSC-Derived Skin Organoids

14 citations , May 2022 in “Stem cell reports”

The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.

SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes

research SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes

4 citations , December 2022 in “Advanced science”

SCD1 is important for hair growth by keeping the connection in skin cells where hair stem cells live stable.

Targeting the Stem Cell Niche: Role of Collagen XVII in Skin Aging and Wound Repair

research Targeting the Stem Cell Niche: Role of Collagen XVII in Skin Aging and Wound Repair

9 citations , January 2022 in “Theranostics”

Collagen XVII is important for skin aging and wound healing.

Regeneration of the Epidermis and Mucosal Epithelium on the Basement Membranes

research Regeneration of the Epidermis and Mucosal Epithelium on the Basement Membranes

2 citations , December 2003 in “Medical electron microscopy”

The skin and mucous membranes can regenerate over the basement membrane after damage, using nearby surviving cells.

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