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GlossaryHemidesmosomes

specialized structures anchoring cells to basement membranes

Hemidesmosomes are specialized structures that anchor cells to the underlying basement membrane, providing stability and support. They play a crucial role in maintaining the integrity of tissues, especially in areas subject to mechanical stress, such as the skin and hair follicles.

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research Wnt/β-Catenin Signaling Stabilizes Hemidesmosomes in Keratinocytes

5 citations , November 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Wnt/β-catenin signaling is important for keeping skin cell attachment structures stable.

SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes

research SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes

4 citations , December 2022 in “Advanced science”

SCD1 is important for hair growth by keeping the connection in skin cells where hair stem cells live stable.

research Evidence That Myc Activation Depletes the Epidermal Stem Cell Compartment by Modulating Adhesive Interactions with the Local Microenvironment

182 citations , May 2003 in “Development”

Myc activation reduces skin stem cells by affecting cell adhesion.

research Immunofluorescence Analysis of the Basement Membrane Zone Components in Human Anagen Hair Follicles

29 citations , July 2003 in “Experimental Dermatology”

The upper hair follicle is stable, while the lower part allows movement during hair growth.

research Co-Factors of LIM Domains (Clims/Ldb/Nli) Regulate Corneal Homeostasis and Maintenance of Hair Follicle Stem Cells

25 citations , October 2007 in “Developmental biology”

Clim proteins are essential for maintaining healthy corneas and hair follicles.

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