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    Glossary Basement Membrane

    thin layer separating epithelial cells from underlying connective tissue

    The basement membrane is a thin, fibrous layer that lies between the epithelial cells (which line surfaces and cavities of organs) and the underlying connective tissue. It provides structural support, acts as a barrier to regulate the movement of cells and molecules, and plays a crucial role in tissue repair and regeneration. In the context of hair, the basement membrane surrounds hair follicles, helping to anchor them in place and maintain their structure.

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    1. Laminin α5 in the keratinocyte basement membrane is required for epidermal–dermal intercommunication Matrix Biology · 2016 · 57 citations
    2. Expression of basement membrane components through morphological changes in the hair growth cycle Developmental Biology · 1985 · 53 citations
    3. Changes in fibronectin, laminin and type IV collagen distribution relate to basement membrane restructuring during the rat vibrissa follicle hair growth cycle. PubMed · 1992 · 45 citations
    4. Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity Journal of Investigative Dermatology · 2000 · 42 citations
    5. Expression of MAEG, a novel basement membrane protein, in mouse hair follicle morphogenesis Experimental Cell Research · 2005 · 41 citations
    6. The distributions of type IV collagen .ALPHA. chains in basement membranes of human epidermis and skin appendages Archives of Histology and Cytology · 2007 · 36 citations
    7. Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions Nature communications · 2021 · 35 citations
    8. Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology British Journal of Dermatology · 2012 · 33 citations
    9. Immunofluorescence analysis of the basement membrane zone components in human anagen hair follicles Experimental Dermatology · 2003 · 29 citations
    10. Basement membrane Laminin and Type IV Collagen in Various Benign and Malignant Adnexal Tumors of the Skin: An Immunohistochemical Study Journal of Investigative Dermatology · 1984 · 28 citations
    11. Re-investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis? 2018 · 13 citations
    12. Basement Membranes in Experimentally Induced Skin Tumors Journal of Investigative Dermatology · 1986 · 8 citations
    13. Collagen XVIII regulates basement membrane integrity : specific effects of its isoforms on the choroid plexus, kidney and hair follicle 2011 · 7 citations
    14. Basement membrane changes in lichen planopilaris Journal of the European Academy of Dermatology and Venereology · 2009 · 7 citations
    15. Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 2 citations
    16. Basement Membrane Matrix Promotes the Efficiency of Hair Follicle Reconstruction In Vivo and Is a Cell Delivery Vehicle for Follicle Regeneration Dermatologic Surgery · 2017 · 1 citations
    17. Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro Mendeley Data · 2026
    18. Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro bioRxiv (Cold Spring Harbor Laboratory) · 2025
    19. An <i>eGFP-Col4a2</i> mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis The Journal of Cell Biology · 2024
    20. An <i>mTurq2-Col4a1</i> mouse model allows for live visualization of mammalian basement membrane development 2023
    21. <i>Col4a2-eGFP</i>mouse model reveals the molecular and functional dynamics of basement membrane remodelling in hair follicle morphogenesis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    22. A Window into Mammalian Basement Membrane Development: Insights from the<i>mTurq2-Col4a1</i>Mouse Model bioRxiv (Cold Spring Harbor Laboratory) · 2023
    23. The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche Cell · 2011 · 294 citations
    24. Faculty Opinions recommendation of Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2021
    25. Expression of Basement Membrane Proteins and Interstitial Collagens in Dermal Papillae of Human Hair Follicles Journal of Investigative Dermatology · 1991 · 85 citations
    26. The Appearance of Four Basement Membrane Zone Antigens in Developing Human Fetal Skin Journal of Investigative Dermatology · 1984 · 65 citations
    27. Immunohistochemical Localization of Basement Membrane Components During Hair Follicle Morphogenesis Journal of Investigative Dermatology · 1984 · 59 citations
    28. Rat Hair Follicle Dermal Papillae Have an Extracellular Matrix Containing Basement Membrane Components Journal of Investigative Dermatology · 1986 · 103 citations
    29. Recombinant humanized collagen combined with nicotinamide increases the expression level of rat basement membrane proteins and promotes hair growth Frontiers in Bioengineering and Biotechnology · 2025
    30. Table 1_Recombinant humanized collagen combined with nicotinamide increases the expression level of rat basement membrane proteins and promotes hair growth.docx OPAL (Open@LaTrobe) (La Trobe University) · 2025