Recombinant Humanized Collagen Combined With Nicotinamide Increases Expression of Rat Basement Membrane Proteins and Promotes Hair Growth

    June 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”
    Youshiqi Zhou (21529319), Boyu Chen (5621660), Shijia Ye (21529322), Haoyu Sun (6298319), Shuyue Wang (833511), Xiaozhen Diao (21529325), Wenhui Wu (372691)
    TLDR The RHC complex with nicotinamide promotes hair growth and health.
    This study investigated the effects of a recombinant human collagen complex (RHC complex) combined with nicotinamide on hair growth using hair follicle stem cells (HFSCs) and rat models. The RHC complex, composed of rhCOL III, rhCOL XVII, and rhCOL XXI, was found to be non-toxic to HFSCs, with a survival rate exceeding 80% after 8 and 16 hours of treatment. It significantly increased intracellular VEGF levels and the content of trichohyalin, enhancing hair follicle structure and function. In rats, a 7-day treatment led to significant hair growth, with increased expression of Integrin, Laminin, and Perlecan, supporting HFSCs stability and promoting their migration and differentiation. The study concludes that the RHC complex is a promising ingredient for promoting hair growth, preventing hair loss, and maintaining hair health.
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