Hair-Cycle Dependent Differential Expression of ADAM 10 and ADAM 12

January 2009 in “ Dermato-endocrinology ”

Shin-Taek Oh, Baik-Kee Cho, Anja Schramme, Paul Gutwein, Wolfgang Tilgen, Jörg Reichrath

ADAM 10 ADAM 12 hair follicles anagen phase catagen phase telogen phase keratinocytes fibroblasts outer root sheath inner root sheath hair cycle regulation therapeutic targets hair-related disorders hair growth phases hair cycle stages

Studysummary This study suggests that ADAM 10 and 12 proteases may play important roles in the regulation of hair cycling through their expression patterns in hair follicle structures.

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In the 2009 study, researchers analyzed the expression of ADAM 10 and ADAM 12 proteases in human hair follicles across different hair cycle stages in samples from 30 individuals. They discovered that ADAM 10 was expressed in the cytoplasm of keratinocytes and fibroblasts in the hair bulb during the early anagen phase and in the outer root sheath during catagen and telogen phases. ADAM 12, however, was not found in early anagen hair bulb keratinocytes but was present in the inner root sheath during anagen IV-V stages and was strongly expressed in the outer root sheath during catagen and telogen. The study concluded that ADAM 10 may be involved in the induction and development of anagen hair follicles, while ADAM 12 may play a role in the differentiation and apoptosis of hair follicle keratinocytes, suggesting their importance in hair cycle regulation and potential as therapeutic targets for hair-related disorders.

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