TLDR Retinoic acid, glucocorticoids, and IGF1 increase IGFBP-3 production in human dermal papilla cells, affecting hair growth.
The study investigated the effects of IGF1, glucocorticoids, and retinoids on the production of insulin-like growth factor binding proteins (IGFBPs) by human dermal papilla (DP) cells. It identified IGFBP-3 as being produced and released by DP cells, with its levels increasing fivefold by retinoic acid, eightfold by dexamethasone, and tenfold by IGF1. This suggests that DP cells are autoregulated by IGFs. The study proposed that retinoids and glucocorticoids inhibit IGF action on DP cells by increasing IGFBP-3 production, which then binds to free IGF1, reducing its availability to stimulate hair elongation and maintenance of the anagen phase. Another IGFBP, tentatively identified as IGFBP-2, was not regulated by these agents.
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