Studysummary This study observed that epidermal growth factor and fibroblast growth factor have distinct roles in sheep skin, with EGF involved in differentiation and FGF in bulb proliferation and fiber growth. Our plain-language summary of this paper — not a Tressless recommendation.
The study explored the roles of epidermal growth factor (EGF) and fibroblast growth factor (FGF) in hair growth induction, focusing on their expression and localization in sheep skin. EGF receptors were found on skin epithelia, and an EGF-like protein was detected in fetal epidermis but not in developing wool follicles, later associating with sebaceous glands and the outer root sheath (ORS). This suggests EGF may influence cell differentiation in the ORS. FGF was found in the epidermis, basal lamina, and follicle plugs during morphogenesis, and later in the ORS and follicle bulb, indicating a role in bulb proliferation and fiber growth.
193 citations
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June 1990 in “Journal of Investigative Dermatology” 114 citations
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September 1985 in “Journal of Investigative Dermatology” 112 citations
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August 1984 in “Journal of Investigative Dermatology” 124 citations
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December 1983 in “Developmental Biology” EGF receptors are crucial for skin cell growth and decrease with age.
72 citations
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January 1983 in “The Anatomical Record” This study found that epidermal growth factor treatment in male mice delayed normal skin development, inhibiting hair growth and follicle development by maintaining birth-level cell proliferation and differentiation for several days.
84 citations
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February 1981 in “Journal of Endocrinology” This study found that epidermal growth factor decreased hair growth rate and altered hair characteristics in neonatal mice, with some effects persisting into subsequent hair generations.
90 citations
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January 1979 in “International review of cytology” This chapter reviews the complexity of hair and wool follicle formation, emphasizing the importance of cytological studies to understand the relationship between cellular components.
521 citations
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January 1954 in “Physiological Reviews” Hair growth is cyclic and influenced mainly by local factors.
111 citations
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March 1951 in “Annals of the New York Academy of Sciences” This article discusses the hair cycle of mice and its relevance in studying experimental carcinogenesis sequences, but it reports no new research findings.
