Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “ Journal of St. Marianna University ”

Mayo Tomochika, Rena Sumie, Ryotaro Miyano, Yasushi Mochizuki, Hajime Inoue, Akiyoshi Kajikawa

human follicle dermal papilla cells human hair follicle-derived keratinocytes Wnt gene family member 5A WNT5A fibroblast growth factor 2 FGF2 vascular endothelial growth factor VEGF exosomes bone morphogenetic protein-2 BMP2 alopecia HFDPC HFK

TLDR Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

The study investigated the effects of products secreted by human hair follicle-derived keratinocytes (HFK) on hair-related gene expression in human follicle dermal papilla cells (HFDPC). The results showed a significant increase in the expression of Wnt gene family member 5A (WNT5A), fibroblast growth factor 2 (FGF2), and vascular endothelial growth factor (VEGF) in HFDPC cultures when HFK supernatant was added. However, when exosomes were removed from the HFK supernatant, there was decreased expression of WNT5A and FGF2, but increased expression of bone morphogenetic protein-2 (BMP2) and VEGF. This suggests that HFDPC hair cycle-related genes are affected by multiple HFK-derived factors, including exosomes, which increase expression of genes that promote hair loss. This could lead to the development of new therapies for alopecia if these signal transduction factors can be identified and their presence and function verified in animals.

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