Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

    January 2022 in “ Journal of St. Marianna University ”
    Mayo Tomochika, Rena Sumie, Ryotaro Miyano, Yasushi Mochizuki, Hajime Inoue, Akiyoshi Kajikawa
    Image of study
    TLDR Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
    The study investigated the effects of products secreted by human hair follicle-derived keratinocytes (HFK) on hair-related gene expression in human follicle dermal papilla cells (HFDPC). The results showed a significant increase in the expression of Wnt gene family member 5A (WNT5A), fibroblast growth factor 2 (FGF2), and vascular endothelial growth factor (VEGF) in HFDPC cultures when HFK supernatant was added. However, when exosomes were removed from the HFK supernatant, there was decreased expression of WNT5A and FGF2, but increased expression of bone morphogenetic protein-2 (BMP2) and VEGF. This suggests that HFDPC hair cycle-related genes are affected by multiple HFK-derived factors, including exosomes, which increase expression of genes that promote hair loss. This could lead to the development of new therapies for alopecia if these signal transduction factors can be identified and their presence and function verified in animals.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 852 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Comprehensive Microneedling Guide

      in Microneedling  290 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Please explain this Minoxidil phenomena

      in Minoxidil  56 upvotes 1 year ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community Keratin microspheres - breakthrough

      in Research/Science  13 upvotes 9 months ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

    Related Research

    3 / 3 results