LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells

August 2020 in “ Frontiers in Genetics ”

Ningxia Zhu, En-Bing Lin, Huan Zhang, Yang Liu, Guiyuan Cao, Congcong Fu, Li Chen, Yang Zeng, Bozhi Cai, Yanping Yuan, Bin Xia, Keng Yen Huang, Lin Changmin

LncRNA H19 Wnt signaling hair follicle regeneration dermal papilla cells miR-29a Wnt suppressors androgenetic alopecia H19 Wnt pathway hair growth DPCs male pattern baldness

TLDR H19 boosts hair growth potential by activating Wnt signaling, possibly helping treat hair loss.

The study found that overexpression of the long non-coding RNA H19 in dermal papilla cells (DPCs) maintained their hair follicle regeneration potential by activating the Wnt signaling pathway. H19 induced miR-29a and downregulated Wnt suppressors, forming a regulatory feedback loop to maintain hair follicle-inducing potential. The study suggests that H19 could be a target for treating androgenetic alopecia.

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