Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

    February 2015 in “ Journal of Investigative Dermatology ”
    James H Upton, Rosalind F. Hannen, Adiam W. Bahta … Michael R. Philpott
    Studysummary This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jidonline.org →
    Discuss this study in the Community →

    Research cited in this study 21

    1. Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells Journal of Biochemistry and Molecular Biology · 2013
    2. Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology Journal of Investigative Dermatology · 2013
    3. Human Hair Follicle and Epidermal Melanocytes Exhibit Striking Differences in Their Aging Profile Involving Catalase ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    4. Intermediate Hair Follicles: A New, More Clinically Relevant Model for Hair Growth Investigations British Journal of Dermatology · 2010
    5. Association of Androgenetic Alopecia with Metabolic Syndrome in Men: A Community-Based Survey British Journal of Dermatology · 2010
    6. Senile Hair Graying: H2O2-Mediated Oxidative Stress Affects Human Hair Color by Blunting Methionine Sulfoxide Repair The FASEB Journal · 2009
    7. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007
    8. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    9. Hormonal Regulation of Hair Follicles Exhibits a Biological Paradox Seminars in Cell & Developmental Biology · 2007
    10. Cell Movement in the Hair Follicle Dermis: More Than a Two-Way Street? Journal of Investigative Dermatology · 2003
    11. Genetic Basis of Male Pattern Baldness Journal of Investigative Dermatology · 2003
    12. Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors British Journal of Dermatology · 2003
    13. Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme: Implications for Hair Growth Control Journal of Investigative Dermatology · 2003
    14. Association Between Smoking and Hair Loss: Another Opportunity for Health Education Against Smoking? Dermatology · 2003
    15. Is Androgenetic Alopecia a Photoaggravated Dermatosis? Dermatology · 2003
    16. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    17. Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001
    18. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    19. Cultured Dermal Papilla Cells of the Rat Vibrissa Follicle: Proliferative Activity, Adhesion Properties, and Reorganization of the Extracellular Matrix In Vitro Archives of Dermatological Research · 1997
    20. Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia Dermatologic Clinics · 1996
    21. Androgens and the Hair Follicle: Cultured Human Dermal Papilla Cells as a Model System PubMed · 1991

    Related research 4

    1. MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells Frontiers in cell and developmental biology · 2020
    2. Improvement of Cell Proliferation and Antioxidant Activity of Silymarin in Hair Follicles Dermal Papillae Isolated from the Human Scalp: Comparison with Vitamin C Effects International Journal of Trichology · 2020
    3. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020
    4. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015