Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

February 2015 in “ Journal of Investigative Dermatology ”

James H Upton, Rosalind F. Hannen, Adiam W. Bahta, Nilofer Farjo, Bessam Farjo, Michael R. Philpott

oxidative stress dermal papilla cells androgenetic alopecia senescence-associated beta-galactosidase low oxygen conditions DPC viability DPC proliferation DPC AGA beta-galactosidase hypoxia cell viability cell proliferation

Studysummary This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp. Our plain-language summary of this paper — not a Tressless recommendation.

This study investigated the effects of oxidative stress on dermal papilla cells (DPC) in men with androgenetic alopecia (AGA). The researchers found that balding DPC were more sensitive to oxidative stress than non-balding DPC, and that oxidative stress may play a role in the pathogenesis of AGA. The study also found that low oxygen conditions (2% O2) led to decreased DPC viability, proliferation, and increased senescence-associated beta-galactosidase activity. The study suggests that oxidative stress-associated senescence in DPC may contribute to the pathogenesis of AGA.

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