Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors

December 2003 in “ British Journal of Dermatology ”

Gianluca Severi, Robert Sinclair, John L. Hopper, Dallas R. English, Margaret R. E. McCredie, Peter Boyle, Graham G. Giles

androgenetic alopecia AGA vertex AGA frontal AGA male pattern baldness

TLDR Hair loss increases with age; alcohol raises risk, more female partners lowers it.

This study aimed to estimate the prevalence and risk factors of androgenetic alopecia (AGA) in men aged 40-69 years in Australia. The study found that the prevalence of vertex and full AGA increased with age, while the proportion of men with only frontal AGA was similar across all age groups. Alcohol consumption was associated with an increased risk of both frontal and vertex AGA, while the lifetime number of female sexual partners was negatively associated with vertex AGA. The study concluded that the prevalence of vertex AGA increases with age, while the prevalence of only frontal AGA appears to be constant. The study suggests that future research on the determinants of AGA should preferably be couched within prospective cohort studies.

View this study on academic.oup.com →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research The Prevalence and Types of Androgenetic Alopecia in Korean Men and Women

157 citations, July 2001 in “British Journal of Dermatology”

AGA more common in men, Koreans have lower rates and unique patterns.

research Vertex Balding, Plasma Insulin-Like Growth Factor 1, and Insulin-Like Growth Factor Binding Protein 3

26 citations, June 2000 in “Journal of The American Academy of Dermatology”

Men with balding at age 45 had higher IGF-1 and lower IGFBP-3, suggesting these factors might be important in male pattern baldness.

research Male-Pattern Hair Loss in Norwegian Men: A Community-Based Study

35 citations, January 2000 in “Dermatology”

Hair loss common in Norwegian men, affecting self-esteem and life quality.

research Fortnightly Review: Male Pattern Androgenetic Alopecia

179 citations, September 1998 in “BMJ”

Hair loss in men is common, treatable, but not curable.

research Association of Benign Prostatic Hyperplasia with Male Pattern Baldness

54 citations, May 1998 in “Urology”

Men with enlarged prostates often have more severe baldness.

Related Community Posts Join

6 / 1000+ results

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 15 upvotes 4 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Scalp tension and thickness of the galea aponeurotica, inflammation and potential treatment pathways

in Research/Science 2 years ago

Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

in Progress Pictures 224 upvotes 8 months ago

A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 37 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

Similar Research

5 / 1000+ results

research Efficacy and Mechanism of Topical Shen Bai Hair Growing Decoction Against Androgenetic Alopecia

February 2024 in “ACS Omega”

The Shen Bai Hair Growing Decoction may help treat hair loss by promoting hair growth and reducing inflammation.

research Does a Male Polycystic Ovarian Syndrome Equivalent Exist?

28 citations, July 2017 in “Journal of Endocrinological Investigation”

Early onset baldness in men may indicate a condition similar to PCOS, linked to heart disease, diabetes, and prostate issues.

research Gender-Specific Association of Androgenetic Alopecia with Metabolic Syndrome in a Middle-Aged Korean Population

37 citations, April 2012 in “British Journal of Dermatology”

Female hair loss linked to metabolic syndrome, not in males.

research Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

1 citations, May 2017 in “InTech eBooks”

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

Association Between Androgenetic Alopecia and Cardiovascular Risk Factors According to BASP Classification in Korean Androgenetic Alopecia

research Association Between Androgenetic Alopecia and Cardiovascular Risk Factors According to BASP Classification in Korean Androgenetic Alopecia

January 2016

Korean patients with androgenetic alopecia may have a higher risk of heart-related health issues and could benefit from early heart screening and healthier lifestyles.