Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

    May 2017 in “ InTech eBooks ”
    Anastasia P. Nesterova, Anton Yuryev
    Studysummary This chapter reviews signaling pathways related to androgenic alopecia in dermal papilla cells of balding human scalps, integrating published information and analysis of molecular interactions, without reporting new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on intechopen.com →
    Discuss this study in the Community →

    Research cited in this study 56

    1. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    2. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    3. Effects of Dihydrotestosterone on Rat Dermal Papilla Cells In Vitro European Journal of Pharmacology · 2015
    4. Androgen Receptor Actions Modify Skin Structure and Chemical Carcinogen-Induced Skin Cancer Susceptibility in Mice Hormones and Cancer · 2015
    5. Hair Follicle Stem Cells: In Vitro and In Vivo Neural Differentiation World journal of stem cells · 2015
    6. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    7. A Review of Adipocyte Lineage Cells and Dermal Papilla Cells in Hair Follicle Regeneration Journal of Tissue Engineering · 2014
    8. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013
    9. Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State Stem Cells · 2013
    10. Androgenetic Alopecia: An Update Indian Journal of Dermatology, Venereology and Leprology · 2013
    11. TGF-β Family Signaling in Stem Cells Biochimica et Biophysica Acta (BBA) - General Subjects · 2012
    12. The Role of Androgen and Androgen Receptor in Skin-Related Disorders Archives of Dermatological Research · 2012
    13. Expression and Function of Nuclear Receptor Co-Activator 4: Evidence of a Potential Role Independent of Co-Activator Activity Cellular and Molecular Life Sciences · 2012
    14. New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence Journal of Investigative Dermatology · 2012
    15. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    16. Dissecting the Bulge in Hair Regeneration Journal of Clinical Investigation · 2012
    17. Trps1 Activates a Network of Secreted Wnt Inhibitors and Transcription Factors Crucial to Vibrissa Follicle Morphogenesis Development · 2011
    18. Androgen Receptor Gene Polymorphisms and Risk for Androgenetic Alopecia: A Meta-Analysis Clinical and Experimental Dermatology · 2011
    19. Differential Expression Analysis of Balding and Nonbalding Dermal Papilla MicroRNAs in Male Pattern Baldness Using a MicroRNA Amplification Profiling Method British Journal of Dermatology · 2011
    20. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    21. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    22. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    23. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    24. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010
    25. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    26. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    27. Keratinocyte Growth Inhibition Through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2009
    28. Analyses of Regenerative Wave Patterns in Adult Hair Follicle Populations Reveal Macro-Environmental Regulation of Stem Cell Activity ˜The œInternational journal of developmental biology · 2009
    29. Stem Cell Factor/c-Kit Signaling in Normal and Androgenetic Alopecia Hair Follicles Journal of Endocrinology · 2008
    30. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007
    31. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    32. The Wnt Inhibitor, Dickkopf 4, Is Induced by Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis Developmental biology · 2007
    33. Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia Human Genetics · 2007
    34. Expression of Sex-Determining Genes in the Scalp of Men with Androgenetic Alopecia Dermatology · 2007
    35. Dynamic Expression of Runx1 in Skin Affects Hair Structure Mechanisms of Development · 2006
    36. Differences in Expression of Specific Biomarkers Distinguish Human Beard from Scalp Dermal Papilla Cells Journal of Investigative Dermatology · 2006
    37. Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2006
    38. The Hair Cycle Journal of Cell Science · 2006
    39. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    40. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    41. Expression of Androgen Receptor Coactivator ARA70/ELE1 in Androgenic Alopecia Journal of Cutaneous Pathology · 2005
    42. Different Gene Expression Profile Observed in Dermal Papilla Cells Related to Androgenic Alopecia by DNA Macroarray Analysis Journal of Dermatological Science · 2004
    43. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    44. Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla Journal of Investigative Dermatology · 2001
    45. Osteopontin Gene Is Expressed in the Dermal Papilla of Pelage Follicles in a Hair-Cycle-Dependent Manner Journal of Investigative Dermatology · 2001
    46. Hair Disorders Primary Care · 2000
    47. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    48. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    49. Cellular And Developmental Aspects Of Androgenetic Alopecia Experimental Dermatology · 1998
    50. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    51. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    52. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    53. Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia Dermatologic Clinics · 1996
    54. The Comparative Histopathology of Male-Pattern Baldness and Senescent Baldness Clinics in Dermatology · 1988
    55. Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex British Journal of Dermatology · 1977
    56. Male Pattern Alopecia: A Histopathologic and Histochemical Study Journal of Cutaneous Pathology · 1975