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    GlossaryAndrogen Receptor Signaling (AR signaling)

    hormones like testosterone bind to receptors, influencing gene expression

    Androgen Receptor Signaling, also known as AR signaling, is a biological pathway where androgens (male hormones like testosterone) bind to androgen receptors in cells. This binding activates the receptors, which then influence the expression of specific genes, affecting various bodily functions such as hair growth, muscle development, and reproductive processes. In the context of hair, AR signaling can play a role in conditions like androgenetic alopecia (pattern hair loss).

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      learn Pyrilutamide

      highly targeted anti-androgen that might have minimal systemic effects

      learn GT20029

      research compound made to degrade androgen receptors in scalp

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      community The mechanism of androgenic alopecia

      in Research/Science  32 upvotes 1 week ago
      DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

      community GT20029 and PP405 the new fin and min that we been waiting for ?

      in Chat  35 upvotes 3 months ago
      PP405 and GT20029 are new hair loss treatments with different mechanisms from traditional options like Minoxidil and Finasteride. PP405 targets hair follicle stem cells to reactivate growth, while GT20029 works as an androgen receptor deleter, both requiring ongoing use for effectiveness.

      community How to reduce scalp DHT as much as possible?

      in Finasteride/Dutasteride  14 upvotes 2 days ago
      The conversation discusses reducing scalp DHT to prevent hair loss, with a focus on using dutasteride, finasteride, and other treatments like RU58841 and minoxidil. It highlights the challenges of managing hair loss while on high testosterone levels, suggesting that dutasteride may be more effective than finasteride in such cases.

      community Is GT20029 supposed to regrow hair as well?

      in Treatment  11 upvotes 2 years ago
      The user is considering switching from finasteride to dutasteride for hair loss. They are unsure if GT20029 can regrow hair, particularly on the temples. Another user mentions that regrowth on finasteride can take up to 2 years.