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research Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases

6 citations , August 2022 in “International Journal of Molecular Sciences”

This review summarizes the role of Ectodysplasin A signaling in skin appendage development and various diseases, noting potential clinical applications but reporting no new research findings.

A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells

research A systematic summary of survival and death signalling during the life of hair follicle stem cells

31 citations , August 2021 in “Stem Cell Research & Therapy”

This review examines the life cycle, biomarkers, and functions of hair follicle stem cells, emphasizing their role in hair loss therapy and other skin and hair disorders, but reports no new clinical results.

Activin A-Induced Signaling Controls Hair Follicle Neogenesis

research Activin A-induced signalling controls hair follicle neogenesis

5 citations , October 2016 in “Experimental Dermatology”

This study found that activin A signaling is crucial for hair follicle neogenesis in human dermal papilla 3D cultures combined with mouse epidermal cells.

research Coordinating the Sculptors: Ectodysplasin-A (EDA) Signaling Cross-Talk with Skeletogenic Pathways

June 2025 in “Preprints.org”

This review examines the complex role of the Ectodysplasin-A pathway in skeletal morphogenesis, emphasizing its interaction with other key signaling pathways, and reports no new experimental findings.

research The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells

46 citations , June 2015 in “Journal of Investigative Dermatology”

This study found that androgen receptor activation in adult mouse skin reduces β-catenin-induced hair follicle growth and sebaceous gland conversion, highlighting its role in stem cell fate decisions.

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community Why does this industry still revolve around 5-AR inhibitors?

40 upvotes 5 years ago

Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stem cell therapy and RNA technology show promise but are not yet available.

community New angles to attack beyond DHT

4 upvotes 2 years ago

Exploring hair loss treatments beyond DHT, including Minoxidil, pyruvate, Gt20029 targeting androgen receptors, and vasodilators. Other options like Kx826, adenosine signaling, growth factor topicals, and microneedling are also discussed.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Minoxidil is NOT an Anti-androgen. No.

in Research/Science 43 upvotes 9 months ago

Minoxidil is not an anti-androgen; it is a growth stimulator and does not lower DHT like finasteride or dutasteride. Minoxidil can cause side effects like facial swelling and anxiety due to its vasodilator properties.

community The mechanism of androgenic alopecia

36 upvotes 11 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

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Clinics

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Experts

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37
Hair Transplant Surgeon
Dr. Shashikiran AR, MD, MBBS, FRGHS
Mysuru, Karnataka, India

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Dr. Shashikiran AR, MD, MBBS, FRGHS