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    Glossary Androgen Receptor Antagonists

    block male hormones like testosterone from affecting tissues

    Androgen Receptor Antagonists, also known as antiandrogens, are medications that block the action of androgens, which are male sex hormones like testosterone. These drugs work by binding to androgen receptors, preventing androgens from exerting their effects on tissues, and are commonly used in the treatment of conditions like prostate cancer, androgenic alopecia (male-pattern baldness), and certain types of acne.

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    Research 10 of 1000+

    1. Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships Current Medicinal Chemistry · 2000 · 204 citations
    2. Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes Bioorganic & medicinal chemistry · 2005 · 45 citations
    3. Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production Bioorganic & Medicinal Chemistry Letters · 2007 · 17 citations
    4. (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production Bioorganic & Medicinal Chemistry Letters · 2007 · 14 citations
    5. Highly efficient nucleophilic addition of alkyl Grignard reagents to 17-ketosteroids in the presence of cerium(III) chloride: Synthesis of 17α-propyl-17β-hydroxy-4-androsten-3-one, an androgen receptor antagonist Tetrahedron Letters · 1994 · 14 citations
    6. 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2009 · 11 citations
    7. Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2007 · 11 citations
    8. Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2009 · 7 citations
    9. Pantolactams as androgen receptor antagonists for the topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2011 · 5 citations
    10. Design, synthesis and biological evaluation of novel 3-oxo-4-oxa-5α-androst-17β-amide derivatives as dual 5α-reductase inhibitors and androgen receptor antagonists Bioorganic & medicinal chemistry letters · 2017 · 3 citations
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    Community 10 of 345

    1. Anyone know by what percentage Pyrilutamide or Ru decrease your androgens? Reddit · 3 Dec 2024
    2. How is the GT20029 different to pyrilutamide as an androgenic antagonist Reddit · 14 Jan 2025
    3. Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy Reddit · 6 Jan 2025
    4. Question about clascoterone acne cream Reddit · 16 Apr 2026
    5. Breezula phase 3 results said to be released next month Reddit · 28 Dec 2024
    6. Pyrilutamide just launched internationally, and all you're doing is hating Reddit · 17 Aug 2024
    7. Shedding again after 6 months of great results. Reddit · 12 Aug 2024
    8. Kintor's email response to me, regarding false advertising, and my proposal for them to develop a topical dut formulation with meaningful efficacy. Reddit · 27 Jul 2024
    9. Topical finasteride might be a lie Reddit · 19 Oct 2023
    10. For people that keep saying Breezula is weaker than fin... Reddit · 20 Aug 2020
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    Learn 8 of 12

    1. Clascoterone Topical androgen-receptor blocker, approved as an acne cream
    2. Spironolactone Blood-pressure and diuretic drug with anti-androgen effects
    3. GT20029 Experimental topical drug designed to break down androgen receptors
    4. Cyproterone a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
    5. Pyrilutamide Experimental topical anti-androgen, also known as KX-826
    6. Bicalutamide Nonsteroidal anti-androgen, originally a prostate cancer drug
    7. RU58841 Experimental topical anti-androgen sold as a research chemical
    8. Fluridil Topical anti-androgen sold as a cosmetic lotion
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