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Glossary Antiandrogen Therapy

reduces or blocks male hormones to treat certain conditions

Antiandrogen Therapy, also known as androgen deprivation therapy (ADT), is a treatment that reduces the levels or blocks the effects of androgens (male hormones like testosterone) in the body. This therapy is commonly used to treat conditions like prostate cancer and androgenic alopecia (male pattern baldness) by slowing the growth of cancer cells or reducing hair loss, respectively.

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Research

5 / 1000+ results

research Spironolactone is an Effective and Well Tolerated Systemic Antiandrogen Therapy for Hirsute Women*

78 citations , May 1989 in “The Journal of Clinical Endocrinology & Metabolism”

This study found that in hirsute women, daily treatment with 200 mg spironolactone significantly reduced hair growth rates and hair shaft diameters on various body areas over 12 months.

research Antiandrogen therapy with spironolactone for the treatment of hidradenitis suppurativa

48 citations , July 2018 in “Journal of The American Academy of Dermatology”

This study observed that treatment with spironolactone significantly improved pain, inflammatory lesion count, and HS-PGA scores among female patients with hidradenitis suppurativa, suggesting its potential as an effective treatment option, even at lower doses, despite no change in Hurley stage or fistula count.

research Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial – Biochemical)

41 citations , February 2021 in “Cureus”

This study found that in males with mild COVID-19, treatment with dutasteride, along with standard therapy, may reduce viral shedding and inflammation compared to placebo.

research ANTIANDROGEN THERAPY IN DERMATOLOGY

32 citations , November 1996 in “International Journal of Dermatology”

This review discusses the use of antiandrogen therapy in dermatology, covering treatments for conditions like acne, hirsutism, and androgenic alopecia but reports no new clinical findings.

research Androgens and Anti-androgen Therapy

30 citations , August 1984 in “Archives of Dermatology”

This review discusses the influence of androgens and antiandrogens on acne, hirsutism, and androgenetic alopecia, focusing on antiandrogen treatments like cyproterone acetate, but reports no new clinical findings.

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Community Join

5 / 705 results

community Female on DHT blockers, need some advice.

5 upvotes 11 months ago

A female experiencing hair loss while on testosterone replacement therapy is using oral Minoxidil, Spironolactone, and finasteride, but still losing hair. Suggestions include switching to dutasteride, using topical anti-androgens, and reducing Nizoral shampoo use to prevent scalp dryness.

community Anyone tried exosome therapy in NYC for hair loss, does it work?

11 upvotes 1 month ago

Exosome therapy for hair loss is questioned, with microneedling and topical minoxidil/dutasteride being more supported treatments. Concerns are raised about testosterone therapy affecting hair loss, and the lack of standardization and approval for exosome products.

community Scalp tension, massage therapy, and Botox! Let’s talk about it!

1 upvotes 1 month ago

The conversation discusses using adjunct therapies like scalp massage and Botox to enhance the effects of DHT inhibitors for hair loss. It also mentions using GHK-cu, finasteride, keto shampoo, and a natural topical DHT-reducing serum for hair regrowth and reduced shedding.

community Cold and Japanese researchers. The Japanese began to suspect something. But they understood the mechanism to some extent. ( Cold shock therapy promotes hair growth in association with upregulation of cold-inducible RNA-binding protein and vascular endothelial growth factor).

36 upvotes 1 year ago

Cold shock therapy may promote hair growth, but cold alone is not effective. Combining treatments like minoxidil, finasteride, cold showers, spicy foods, and exercise may enhance results.

community I Get Side-Effects from Anti-Androgens

8 upvotes 6 years ago

Someone looking for solutions to their hair loss, who has tried and failed to tolerate anti-androgen treatments such as finasteride, CB-03-01, RU58841, and Eucapil. The user is seeking advice and understanding of their extreme sensitivity to these treatments.

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Learn

6 / 800 results

learn Bicalutamide

Nonsteroidal anti-androgen, originally a prostate cancer drug

learn Spironolactone

Blood-pressure and diuretic drug with anti-androgen effects

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Dutasteride

5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

learn Pyrilutamide

Is pyrilutamide a safer alternative to oral antiandrogens like finasteride? Pyrilutamide (KX-826) is an unapproved, investigational topical antiandrogen whose safety data come from short-term sponsor announcements, not peer-reviewed studies. No study has compared it with finasteride, so there is no evidence that it is safer.

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is an investigational topical androgen-receptor degrader. One 12-week Phase II trial in 180 Chinese men found two of four regimens beat placebo on hair count; it is not approved or available.

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