Spironolactone Is an Effective and Well-Tolerated Systemic Antiandrogen Therapy for Hirsute Women

    May 1989 in “ The Journal of Clinical Endocrinology & Metabolism ”
    Julian H. Barth, C.A. Cherry, Fenella Wojnarowska, R.P.R. Dawber
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    TLDR Spironolactone effectively reduces hair growth in women with hirsutism and is generally well-tolerated.
    In 1989, a study involving 22 hirsute women, of which 18 completed the study, found that daily treatment with 200 mg of spironolactone significantly reduced hair growth on various body parts, with mean daily linear growth rates and hair shaft diameters showing reductions ranging from 15% to 66% after 12 months. The treatment also decreased daily hair volume production by 34% to 60%. While six women experienced midcycle vaginal bleeding and three saw a regulation of previously irregular menstrual cycles, only one participant discontinued treatment due to suspected hyperkalemia. Overall, the study concluded that spironolactone is an effective and well-tolerated systemic antiandrogen therapy for hirsutism in women, despite the occurrence of menstrual irregularities in 67% of the participants. No serious adverse effects were reported.
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      in Progress Pictures  224 upvotes 1 year ago
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      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  53 upvotes 2 years ago
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      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  33 upvotes 6 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community Trans: Do I need to use Finnasteride?

      in Transgender 2 years ago
      A transgender individual is starting spironolactone and estradiol for hormone replacement therapy (HRT) and is considering adding finasteride to help with hair loss. They are also planning to use minoxidil and microneedle, but are unsure if they need to use another anti-androgen or more aggressive treatments. A respondent advises against using pyri and suggests waiting to see if the HRT alone is sufficient before becoming dependent on minoxidil.

      community Female on DHT blockers, need some advice.

      in Research/Science  3 upvotes 5 months ago
      A female experiencing hair loss while on testosterone replacement therapy is using oral Minoxidil, Spironolactone, and finasteride, but still losing hair. Suggestions include switching to dutasteride, using topical anti-androgens, and reducing Nizoral shampoo use to prevent scalp dryness.

      community Are these all the anti androgen products?

      in Treatment  6 upvotes 2 years ago
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