The Effect of Spironolactone on Genital Skin 5α-Reductase Activity

    August 1985 in “ Journal of steroid biochemistry/Journal of Steroid Biochemistry ”
    P. Serafini, Jerome A. Catalino, Rogerio A. Løbo
    Studysummary This study found that spironolactone directly inhibits 5 alpha-reductase activity in hirsute women, resulting in decreased conversion of testosterone to dihydrotestosterone, which may contribute to its therapeutic effects.
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    Research cited in this study 5

    1. The Effects of Two Doses of Spironolactone on Serum Androgens and Anagen Hair in Hirsute Women Fertility and sterility · 1985
    2. Androgen Metabolism in Hirsute Patients Treated with Cyproterone Acetate Journal of steroid biochemistry/Journal of Steroid Biochemistry · 1984
    3. Treatment of Hirsutism With Spironolactone JAMA · 1982
    4. A Novel Use of Spironolactone: Treatment of Hirsutism ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 1980
    5. New Therapeutic Approach to the Hirsute Patient Fertility and sterility · 1979