5α-Reductase Inhibitors: Progress and Therapeutic Potential

    January 2001 in “ Advances in protein chemistry
    John D. McConnell, Elizabeth Stoner
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    TLDR 5α-reductase inhibitors help treat disorders caused by DHT and have potential for future therapies.
    This chapter reviewed the progress in developing and using 5α-reductase inhibitors to treat disorders mediated by dihydrotestosterone (DHT), a key androgen. It highlighted the significant advancements in understanding androgen biology through these inhibitors. The chapter also discussed the potential of new 5α-reductase inhibitors in development to further elucidate the role of DHT and 5α-reductase in androgen biology and their therapeutic potential for androgenic disorders. The importance of DHT as a potent androgen, distinct from testosterone, was underscored by studies from 1974 on a rare inborn disorder caused by 5α-reductase deficiency, which affects male sexual differentiation.
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