Male Androgenetic Alopecia

July 2002 in “ Clinical and Experimental Dermatology ”

Rolf-Dieter Hoffmann

androgenetic alopecia male pattern baldness androgens DHT 5α-reduced metabolite testosterone androgen metabolism AGA male pattern baldness dihydrotestosterone

TLDR DHT, a testosterone byproduct, causes male pattern baldness.

This document from 20 years ago discusses male androgenetic alopecia (AGA), also known as male pattern baldness. The paper explores the effects of androgens on hair growth and the pathogenesis of AGA. The study found that hair follicles in certain areas of the body are androgen-dependent, and that the principal mediator of androgen-dependent hair loss is DHT, the 5α-reduced metabolite of testosterone. The paper also discusses the role of androgen metabolism in hair growth and the conversion of weak androgens to more potent androgens. The study concludes that further research is needed to fully understand the mechanisms behind AGA.

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