17α-Estradiol Induces Aromatase Activity in Intact Human Anagen Hair Follicles Ex Vivo

    August 2002 in “ Experimental Dermatology ”
    R. Hoffmann, S Niiyama, A. Huth … Rudolf Happle
    Studysummary This study found that 17α‐estradiol increases aromatase activity in female hair follicles, which may explain its beneficial effects in treating androgenetic alopecia.
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    Research cited in this study 11

    1. 5-Alpha Reductase Deficiency Current Opinion in Endocrinology, Diabetes and Obesity · 2014
    2. Enzymology of the Hair Follicle PubMed · 2001
    3. Influence of Estrogens on Androgen Metabolism in Different Subunits of Human Hair Follicles PubMed · 2001
    4. Current Understanding of Androgenetic Alopecia: Part I - Etiopathogenesis PubMed · 2000
    5. On The Effect Of Estrogen Receptor Agonists And Antagonists On The Mouse Hair Follicle Cycle Journal of Investigative Dermatology · 1998
    6. 5α-Reductase Activity in the Human Hair Follicle Concentrates in the Dermal Papilla Archives of Dermatological Research · 1998
    7. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    8. An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation Proceedings of the National Academy of Sciences of the United States of America · 1996
    9. Local Therapy of Androgenetic Alopecia with 17α-Estradiol Dermatology · 1980
    10. Local Therapy of Androgenetic Alopecia with 17 Alpha-Estradiol: A Controlled, Randomized Double-Blind Study PubMed · 1980
    11. Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex British Journal of Dermatology · 1977

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