On The Effect Of Estrogen Receptor Agonists And Antagonists On The Mouse Hair Follicle Cycle
July 1998
in “
Journal of Investigative Dermatology
”
TLDR β-estradiol slows hair growth in mice.
The study initially reported errors in the concentration of estrogen receptor agonists and antagonists used in experiments on mouse hair follicle cycles. Upon repeating the experiments with the correct concentrations, it was found that β-estradiol inhibited the progression of spontaneous anagen in pigmented mice (C57B16). This led to new insights into the role of estrogen receptor-mediated signaling in murine hair growth control. The researchers acknowledged the oversight and expressed gratitude to Drs. Oh and Smart for highlighting the phenomenon, while an editorial note apologized for not allowing a response to the original letter.