210 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”
This review discusses the role of intrinsic skin signals, rather than serum signals, in regulating melanin synthesis and hair pigmentation, but reports no new experimental data.
This study found that active BMP signaling prevents epithelial stem cell activation and expansion in hair follicles, while its inhibition leads to HF stem/progenitor cell overproduction and matricomas.
161 citations
,
June 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”
This study found that the switch-off of melanogenesis during the hair cycle in C57 BL-6 mice is a gradual and stochastic process starting in mid anagen VI, with specific biochemical markers indicating the transition to catagen.
142 citations
,
February 1985 in “Fertility and sterility”
This study found that spironolactone reduced serum androstenedione and anagen hair shaft diameter in hirsute patients but did not significantly alter unbound testosterone levels, suggesting its effects are primarily peripheral.
A company is developing a topical dutasteride that targets hair follicles without significantly affecting systemic DHT levels, with trials underway to measure its effectiveness. Users discuss the potential benefits and skepticism around the formulation compared to existing treatments.
Anagenica.com has poor customer service but delivers quality hair loss products like liposomal dutasteride. OP recommends ordering directly from Farmacia Tristiana for better service.
The user is confused about the pricing and concentration of pyrilutamide powder for hair loss treatment. They calculate that 500mg of pyrilutamide can make ten 1ml applications of a 5% solution, costing $119.
The conversation is about the availability of gt20029 for hair loss treatment, indicating that it will not be available for purchase soon. No specific treatments were discussed.
People are discussing Anagen's "Smooth Release" oral minoxidil, with some users reporting no side effects or hair growth yet. There are concerns about a potential lawsuit with Veradermics over intellectual property, but no confirmed legal action has been found.