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research Review of the effects of 17α-estradiol in humans: a less feminizing estrogen with neuroprotective potential

26 citations , February 2009 in “Drug Development Research”

This article reviews the potential neuroprotective effects of 17α‐estradiol in neurodegenerative diseases and highlights its possibly lower toxicity compared to more feminizing hormones, but it reports no new clinical findings.

research Effects of 17-β-Estradiol and ICI 182 780 on Hair Growth in Various Strains of Mice

32 citations , December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

This study found that the effectiveness of 17-beta-estradiol in inhibiting hair growth depends on its application method, and noted significant sex differences in response to 17-alpha-estradiol in male and female mice.

research Compatibility of 17-a-estradiol, Caffeine, Clobetasol Propionate, Finasteride Melatonin, Metronidazole, Spironolactone, Tretinoin, and Triamcinolone in Trichosol, a Natural Vehicle for Hair Solutions.

May 2025 in “PubMed”

This study evaluated the stability of multiple active ingredients in TrichoSol™ for use in alopecia treatments, finding varying stability durations at room temperature—up to 180 days for some ingredients—supporting its use as a compounding vehicle in personalized therapies.

research Therapeutic Efficacy of a Combination Therapy of Topical 17α-Estradiol and Topical Minoxidil on Female Pattern Hair Loss: A Noncomparative, Retrospective Evaluation

6 citations , January 2017 in “Annals of Dermatology”

In this study, Korean women with female pattern hair loss who used a combination of topical 0.025% 17α-estradiol and 3% minoxidil saw significant increases in total hair count and hair caliber over six months.

research Peculiar hypertrichosis in a patient affected by frontal fibrosing alopecia with pseudo "fringe sign"

2 citations , July 2020 in “Giornale italiano di dermatologia e venereologia”

A woman with frontal fibrosing alopecia experienced unusual hair growth after using a specific topical lotion.

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community Hypothetically, if estradiol has been a "cure" for hair loss, could one apply estradiol topically and just take an estrogen blocker and/or testosterone to offset the systematic effects?

8 upvotes 1 year ago

Topical estradiol may help with hair loss but can have systemic effects, like reduced testosterone production. Using estrogen blockers can have negative side effects, such as joint pain and reduced sex drive.

community I live in the US. Where are most reputable places to purchase either Alfatradiol or Pyralutamide?

3 upvotes 1 year ago

The user is considering adding Alfatradiol or Pyralutamide to their current hair loss treatment of oral Dutasteride and Minoxidil. They are seeking advice on experiences and purchasing options for these products in the US.

community If you could get for Christmas your own personalised topical anti hair loss serum that has the best the current science can offer, what would it contain and at what concentration?

2 upvotes 1 year ago

A personalized topical anti-hair loss serum could include high-dose setipiprant, high-dose CB 03-01, low-dose finasteride, minoxidil, latanoprost, and tretinoin. These ingredients are suggested for their potential effectiveness in promoting hair growth.

community Starting a topical stack my derm suggested, would like y'alls opinion on it. Bimatoprast 0.03%, Dut 0.1%, Min 7%, Treinoin 0.015%

in Chat 2 upvotes 1 year ago

A user is considering a topical hair loss treatment with Bimatoprost 0.03%, Dutasteride 0.1%, Minoxidil 7%, and Tretinoin 0.015%, and is unsure about adding oral finasteride due to potential side effects. Another user suggests microneedling and mentions the benefits of a high protein and omega-3 diet for hair health.

community DIY Minoxidil mix with Fin, Caffeine, Cetirizine, and Melatonin?

4 upvotes 1 year ago

A user plans to create a custom topical solution by adding finasteride, caffeine, cetirizine, and melatonin to a minoxidil bottle, questioning the stability and effectiveness of this mix. Concerns include potential crystallization and solution muddiness with added ingredients.

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