Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne

    July 1998 in “ Journal of Cutaneous Medicine and Surgery ”
    Marty E. Sawaya, Alan R. Shalita
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    TLDR Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.
    This document is a compilation of summaries of various studies that investigate the relationship between androgen receptor polymorphisms and androgenetic alopecia, hirsutism, and acne. The studies suggest that shorter CAG repeat lengths in the androgen receptor gene may increase the risk of androgen-related skin disorders such as androgenetic alopecia and hirsutism, while longer CAG repeat lengths may be linked to acne. The findings suggest that genetic variations in the androgen receptor may play a role in the development of these conditions and could be a potential treatment option in the future. However, more research is needed to fully understand this connection.
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