Increased Androgen Receptor Messenger RNA in Frontal-Parietal Hair Follicles of Women with Androgenetic Alopecia

The study found that women with androgenetic alopecia (AGA) have higher levels of androgen receptor messenger RNA (AR mRNA) in the frontal-parietal (FP) hair follicles compared to the occipital region. The study suggests that the increased AR mRNA levels in the FP region may contribute to the development of AGA in women. The study also found a correlation between the amount of AR mRNA expressed in hair follicles and the number of CAG repeats encoded by exon 1 of the AR gene, with shorter alleles presenting higher expression rates and an increased expression of the AR protein. The study suggests that enhanced AR expression can increase sensitivity to androgens in the dermal papilla cells of AGA patients.