Use of Genetics in the Prediction of Success in Male Pattern Hair Loss Therapy and Mechanistic Studies

    February 2026 in “ Frontiers in Pharmacology ”
    Gustavo Torres De Souza, Greg Williams, Carolina C. V. Silva … Valentina Russo
    Studysummary This review suggests a shift toward genetically informed treatments for male pattern hair loss by integrating genetic insights and pharmacogenetic markers into therapeutic decision-making.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on public-pages-files-2025.frontiersin.org →
    Discuss this study in the Community →

    Research cited in this study 68

    1. Alopecia Areata Nature Reviews Disease Primers · 2025
    2. Therapeutic And Clinical Potential Of Adipose-Derived Stem Cell Secretome For Skin Regeneration Cells · 2025
    3. Genetic Insights Into Acne, Androgenetic Alopecia, And Alopecia Areata: Implications For Mechanisms And Precision Dermatology Cosmetics · 2025
    4. Androgenetic Alopecia Nature Reviews Disease Primers · 2025
    5. Efficient Silencing of Androgen Receptor Gene via UTR-Targeting siRNAs for Androgenetic Alopecia Therapy Journal of Medicinal Chemistry · 2025
    6. Wnt/β-Catenin Signaling Pathway Targeting Androgenetic Alopecia: How Far Can We Go Beyond Minoxidil and Finasteride? Journal of Medicinal Chemistry · 2025
    7. 26-SNP Panel Aids Guiding Androgenetic Alopecia Therapy and Provides Insight into Mechanisms of Action Cosmetics · 2025
    8. Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment Drug Design Development and Therapy · 2025
    9. Pathophysiological Mechanisms of Hair Follicle Regeneration and Potential Therapeutic Strategies Stem Cell Research & Therapy · 2025
    10. Hair Growth Stimulated by Allogenic Adipose-Derived Stem Cells Supplemented with ATP in a Mouse Model of Dihydrotestosterone-Induced Androgenetic Alopecia Stem Cell Research & Therapy · 2025
    11. Subcutaneous Injection of Genetically Engineered Exosomes for Androgenic Alopecia Treatment Frontiers in Bioengineering and Biotechnology · 2025
    12. The Health Benefits Of Hair Transplant Surgery Aesthetic Surgery Journal · 2025
    13. Characterization and Management of Adverse Events of Low-Dose Oral Minoxidil Treatment for Alopecia: A Narrative Review Journal of Clinical Medicine · 2025
    14. Effectiveness of Exosome Treatment in Androgenetic Alopecia: Outcomes of a Prospective Study Aesthetic Plastic Surgery · 2024
    15. Application of Multi-Omics Techniques to Androgenetic Alopecia: Current Status and Perspectives Computational and Structural Biotechnology Journal · 2024
    16. Platelet-Rich Fibrin: A Review of Its Role as a New Treatment in Androgenetic Alopecia Journal of cosmetic dermatology · 2024
    17. Utilizing SNP Association Analysis as a Prospective Approach for Personalizing Androgenetic Alopecia Treatment Dermatology and therapy (Internet) · 2024
    18. Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia Medicina-lithuania · 2023
    19. Alopecia – New Building Blocks Journal of the American Academy of Dermatology · 2023
    20. Male-Pattern Hair Loss: Comprehensive Identification of the Associated Genes as a Basis for Understanding Pathophysiology Medizinische Genetik · 2023
    21. Human Stem Cell Use in Androgenetic Alopecia: A Systematic Review Cells · 2023
    22. Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia Molecular Pharmaceutics · 2022
    23. The Psychological Consequences of Androgenetic Alopecia: A Systematic Review Journal of Cosmetic Dermatology · 2022
    24. Weekly Treatment with SAMiRNA Targeting the Androgen Receptor Ameliorates Androgenetic Alopecia Scientific Reports · 2022
    25. The Inflammatory Component of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2021
    26. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    27. Perifollicular Inflammation and Follicular Spongiosis in Androgenetic Alopecia Journal of The American Academy of Dermatology · 2021
    28. Androgenetic Alopecia: Update on Etiology Dermatological reviews · 2021
    29. Sulfotransferase SULT1A1 Activity in Hair Follicle: A Prognostic Marker of Response to Minoxidil Treatment in Androgenetic Alopecia Postepy Dermatologii I Alergologii · 2020
    30. Hormonal Effects on Hair Follicles International journal of molecular sciences · 2020
    31. Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil Treatment in Brazilian Female Pattern Hair Loss Patients Dermatologic Therapy · 2019
    32. Female Androgenetic Alopecia: An Update on Diagnosis and Management American Journal of Clinical Dermatology · 2019
    33. A Randomized, Investigator-Blinded, Controlled, Split-Scalp Study of the Efficacy and Safety of a 1550-nm Fractional Erbium-Glass Laser, Used in Combination with Topical 5% Minoxidil Versus 5% Minoxidil Alone, for the Treatment of Androgenetic Alopecia Lasers in Medical Science · 2019
    34. Dissection of Genetic Variation and Evidence for Pleiotropy in Male Pattern Baldness Nature Communications · 2018
    35. Minoxidil in the Treatment of Androgenetic Alopecia Dermatologic Therapy · 2018
    36. Genetic and Molecular Aspects of Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2018
    37. GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk Nature Communications · 2017
    38. Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice Scientific Reports · 2017
    39. Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways British Journal of Dermatology · 2017
    40. Meta-Analysis Identifies Novel Risk Loci and Yields Systematic Insights into the Biology of Male-Pattern Baldness Nature communications · 2017
    41. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    42. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    43. Clinical Utility and Validity of Minoxidil Response Testing in Androgenetic Alopecia Dermatologic Therapy · 2014
    44. Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness? Experimental Dermatology · 2014
    45. Androgenetic Alopecia, Metabolic Syndrome, and Insulin Resistance: Is There Any Association? A Case-Control Study Indian Dermatology Online Journal · 2014
    46. Novel Enzymatic Assay Predicts Minoxidil Response in the Treatment of Androgenetic Alopecia Dermatologic Therapy · 2013
    47. Evidence for a Polygenic Contribution to Androgenetic Alopecia British Journal of Dermatology · 2013
    48. Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases PLOS Genetics · 2012
    49. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    50. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    51. Identification of Telogen Markers Underscores That Telogen Is Far from a Quiescent Hair Cycle Phase ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    52. The Hair Cycle and Vitamin D Receptor Archives of Biochemistry and Biophysics · 2011
    53. A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2011
    54. Prolactin: An Emerging Force Along the Cutaneous–Endocrine Axis Trends in Endocrinology and Metabolism · 2010
    55. Eyelash Growth from Application of Bimatoprost in Gel Suspension to the Base of the Eyelashes Ophthalmology · 2010
    56. Association of Androgenetic Alopecia with Metabolic Syndrome in Men: A Community-Based Survey British Journal of Dermatology · 2010
    57. Genome-Wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26 American Journal of Human Genetics · 2008
    58. The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008
    59. A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2007
    60. Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function Proceedings of the National Academy of Sciences · 2007
    61. Prolactin Delays Hair Regrowth in Mice Journal of Endocrinology · 2006
    62. Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression American Journal of Pathology · 2006
    63. Pharmacogenetic Analysis of Human Steroid 5α Reductase Type II: Comparison of Finasteride and Dutasteride Journal of Molecular Endocrinology · 2005
    64. Hypertrichosis of the Eyelashes Caused by Bimatoprost Journal of the American Academy of Dermatology · 2004
    65. A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    66. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    67. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    68. Male Androgenetic Alopecia Clinical and Experimental Dermatology · 2002