Efficient Silencing of Androgen Receptor Gene via UTR-Targeting siRNAs for Androgenetic Alopecia Therapy

    September 2025 in “ Journal of Medicinal Chemistry ”
    Di Feng, Xinli Fan, Yuqiang Hu … Xinjing Tang
    Studysummary This study evaluated a chemically modified siRNA, AR-27 E-Chol, which effectively promoted hair regrowth and reduced androgen receptor gene expression in a DHT-induced mouse model of androgenetic alopecia, suggesting its potential as a novel therapeutic candidate.
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    Research cited in this study 18

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