Genomic Markers and Personalized Medicine in Androgenetic Alopecia: A Comprehensive Review

    August 2024 in “ Cosmetics
    Laura Vila, Valentina Russo, Gustavo Torres de Souza
    TLDR Personalized treatments for hair loss are becoming more effective by using genetic information.
    The review highlights the potential of pharmacogenetics in treating androgenetic alopecia (AGA) by identifying genetic markers to guide personalized therapy, enhancing treatment efficacy and patient satisfaction. Genetic studies have identified SNPs associated with AGA, involving genes in androgen metabolism, prostaglandin pathways, and vasodilation. Pharmacogenetics can personalize treatments with drugs like minoxidil and finasteride based on genetic variants. Additionally, RNA interference (RNAi) technology, including siRNAs and asiRNAs, shows promise in reducing androgen receptor levels and promoting hair growth, offering new treatment avenues for AGA. Integrating these genetic insights into clinical practice could transform AGA management.
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