Analysis of the MicroRNA Expression Profile of Normal Human Dermal Papilla Cells Treated with 5α-Dihydrotestosterone

March 2012 in “ Molecular Medicine Reports ”

Myung J. Lee, Hwa Jun, Kyung Mi Lim, Ok‐Kyu Lee, Seunghee Bae, Chun‐Ho Kim, Kee‐Ho Lee, Yu Na Lee, Kyu Joong Ahn, Sungkwan An

5α-dihydrotestosterone DHT normal human dermal papilla cells nHDPCs reactive oxygen species ROS senescence microRNAs miRNAs miRNA-125a-3p miR-485-5p androgenetic alopecia cell proliferation cell migration hair follicle cells oxidative stress hair loss male pattern baldness

Studysummary This study found that DHT treatment led to reduced cell growth, increased cell death, cell cycle arrest, ROS production, and senescence in normal human dermal papilla cells, potentially mediated by altered miRNA expression.

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The study analyzed the impact of 5α-dihydrotestosterone (DHT) on normal human dermal papilla cells (nHDPCs), discovering that DHT treatment led to decreased cell growth, cell death, G2 cell cycle arrest, increased reactive oxygen species (ROS) production, and senescence. It was found that 61 microRNAs (miRNAs) were significantly affected, with 55 being upregulated and 6 downregulated. The altered miRNAs included miRNA-125a-3p and miR-485-5p, which are known to repress cell proliferation and migration. These changes in miRNA expression suggest potential mechanisms for the effects of DHT on nHDPCs, which may contribute to the development of androgenetic alopecia. The study provided evidence that miRNA regulation is involved in the cellular response to DHT treatment in hair follicle cells.

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