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    Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells

    January 2006 in “ Skin Pharmacology and Physiology ”
    Anna Winiarska, Nathalie Mandt, Hartwig Kamp … Ulrike Blume-Peytavi
    Studysummary This study found that testosterone and 5α-dihydrotestosterone induced apoptosis in dermal papilla cells from nonbalding scalp regions, suggesting a high androgen stimulus can trigger cell death related to androgenetic alopecia.
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    Research cited in this study 19

    1. Apoptosis Coordinates With Proliferation And Differentiation During Human Hair Follicle Morphogenesis Journal of dermatological science · 2005
    2. An Investigation of Apoptosis in Androgenetic Alopecia PubMed · 2003
    3. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    4. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    5. An Investigation of Apoptosis in Androgenetic Alopecia American Journal of Dermatopathology · 2002
    6. Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle Journal of Cutaneous Medicine and Surgery · 2002
    7. Androgen Responsive Genes as They Affect Hair Growth PubMed · 2001
    8. Androgenetic Alopecia in Men and Women Clinics in Dermatology · 2001
    9. Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999
    10. Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells British journal of dermatology/British journal of dermatology, Supplement · 1999
    11. Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo and In Vitro Journal of Investigative Dermatology · 1998
    12. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    13. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    14. The 5 Alpha-Reductase System and Its Inhibitors Dermatology · 1996
    15. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995
    16. Mechanism of Action of Androgen in Hair Follicles Journal of dermatological science · 1994
    17. Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    18. The Control of Hair Growth: An Overview Journal of Investigative Dermatology · 1993
    19. Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp Journal of Endocrinology/Journal of endocrinology · 1992

    Related research 1

    1. Age-Dependent Regulation by Androgens of Gene Expression in the Anterior Hypothalamus and Stress-Induced Release of Adrenal Hormones in Adolescent and Adult Male Rats Journal of neuroendocrinology · 2019