Androgenetic Alopecia in Men and Women

March 2001 in “ Clinics in Dermatology ”

Rodney Sinclair, Rodney P.R. Dawber

From the encyclopedia

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

Frontline, gold standard treatment for combatting androgenic alopecia

Studysummary This article discusses treatment approaches for female pattern hair loss and concludes that available medical treatments are effective in reversing or stabilizing the condition in most cases of mild-to-moderate severity. Our plain-language summary of this paper — not a Tressless recommendation.

This document from 22 years ago discusses androgenetic alopecia in both men and women. It covers topics such as the genetics and hormonal factors involved in hair loss, as well as the psychological effects of alopecia. The document includes references to various studies and research on the subject, including the prevalence of endocrine disorders and polycystic ovaries in patients with hirsutism or androgenic alopecia. It also discusses the differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells. Overall, the document provides a comprehensive overview of androgenetic alopecia and its various aspects. The document also discusses various treatments for androgenetic alopecia in men and women, including medications such as cyproterone acetate, flutamide, and finasteride, as well as scalp surgery. The article also mentions future developments in the field, such as second generation steroidal 5a reductase inhibitors and gene therapy.

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Research cited in this study

43 / 43 results

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research The Psychosocial Consequences of Androgenetic Alopecia: A Review of the Research Literature

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research Serum Androgens and Genetic Linkage Analysis in Early Onset Androgenetic Alopecia

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research Finasteride in the Treatment of Men with Frontal Male Pattern Hair Loss

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research Diffuse Hair Loss: Causes, Diagnosis, and Treatment

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research The Midline Part: An Important Physical Clue to the Clinical Diagnosis of Androgenetic Alopecia in Women

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research Novel Agents for the Treatment of Alopecia

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research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factors in Response to Testosterone Unlike Scalp Cells

51 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers found that while both beard and scalp dermal papilla cells release similar autocrine growth factors, only beard cells increased production and response with testosterone, suggesting these factors enhance androgen-induced hair growth.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

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research Fortnightly Review: Male Pattern Androgenetic Alopecia

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research Hirsutism II: Treatment

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research Increased Scalp Skin and Serum 5 Alpha-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia

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research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

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research Hair Problems in Women: A 1997 Study on Prevalence, Psychological Impact, and Treatment Approaches

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This study found that women with androgenetic alopecia and alopecia areata had significantly lower serum ferritin levels compared to women without hair loss.

research Diffuse Hypertrichosis During Treatment with 5% Topical Minoxidil

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research The Use of Dermal Papilla Cells in Studies of Normal and Abnormal Hair Follicle Biology

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research Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia

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Too much androgen can cause hair loss; finasteride may help.

research The 5 Alpha-Reductase System and Its Inhibitors

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A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia

research A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia

135 citations , August 1994 in “Clinical Endocrinology”

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research Androgens and Human Hair Growth

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research Androgenetic Alopecia in the Female: Treatment with 2% Topical Minoxidil Solution

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research Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects

222 citations , October 1993 in “Journal of The American Academy of Dermatology”

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research Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia

309 citations , May 1993 in “Journal of The American Academy of Dermatology”

This study concluded that horizontal sections of scalp biopsy specimens provide more diagnostic information for male pattern androgenetic alopecia than vertical sections and can predict hair regrowth potential following topical minoxidil therapy.

research The Psychological Effects of Androgenetic Alopecia in Men

192 citations , June 1992 in “Journal of The American Academy of Dermatology”

Hair loss can cause low self-esteem, anxiety, and depression in men.

research Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp

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research Cyproterone Acetate for Severe Hirsutism: Results of a Double-Blind Dose-Ranging Study

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research Natural Progression of Male Pattern Baldness in Young Men

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research Natural History of Androgenetic Alopecia

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research The Comparative Histopathology of Male-Pattern Baldness and Senescent Baldness

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research Patterned Androgenic Alopecia in Women

130 citations , May 1988 in “Journal of The American Academy of Dermatology”

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research Topical Minoxidil in Male Pattern Baldness: Effects of Discontinuation of Treatment

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research Safety and Efficacy of Topical Minoxidil in the Management of Androgenetic Alopecia

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research Use of Topical Minoxidil in the Treatment of Male Pattern Baldness

53 citations , March 1987 in “Journal of The American Academy of Dermatology”

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research Long-Term Follow-Up of Men with Male Pattern Baldness Treated with Topical Minoxidil

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research Topical Tretinoin for Hair Growth Promotion

73 citations , October 1986 in “Journal of the American Academy of Dermatology”

This study found that a combination of topical tretinoin and 0.5% minoxidil resulted in terminal hair regrowth in 66% of subjects with androgenetic alopecia over one year.

Oral Spironolactone Therapy for Female Patients with Acne, Hirsutism, or Androgenic Alopecia