Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factors in Response to Testosterone Unlike Scalp Cells

    M. Julie Thornton, Kazuto Hamada, A.G. Messenger, Valerie A. Randall
    TLDR Beard cells, unlike scalp cells, produce growth factors in response to testosterone, which may explain differences in hair growth.
    The study concluded that androgen-dependent beard dermal papilla cells secreted autocrine growth factors in response to testosterone, unlike nonbalding scalp dermal papilla cells. Beard cells showed a significant increase in DNA synthesis and mitogenic activity when exposed to testosterone, suggesting a unique androgen response that could explain the androgen-induced enlargement of hair follicles in beard growth. This differential behavior highlighted the potential role of these factors in androgen-dependent hair disorders and the need for further research to identify the specific mitogenic factors involved.
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