Optimization of the Reconstruction of Dermal Papilla-Like Tissues Employing Umbilical Cord Mesenchymal Stem Cells

    February 2010 in “ Biotechnology and bioprocess engineering ”
    Bo-Young Yoo, Youn-Ho Shin, Hee-Hoon Yoon, Young-Kwon Seo, Kye‐Yong Song, Jung-Keug Park
    TLDR Using umbilical cord stem cells can help create hair-growing tissues more affordably.
    The study aimed to optimize the reconstruction of dermal papilla-like tissues (DPLTs) using umbilical cord-derived mesenchymal stem cells (UC-MSCs) to treat alopecia. Researchers previously demonstrated that UC-MSCs could be isolated and expanded from Wharton's Jelly, forming aggregates similar to native dermal papilla in special media, which could induce new hair follicles. The study focused on optimizing the differentiation step of DPLTs, which requires hepatocyte growth factor (HGF), a relatively expensive component. By evaluating the effects of cell inoculation density and growth factors during differentiation, the study sought to reduce the costs associated with cell therapy using MSCs.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 1000+ results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  43 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  735 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Vitamin C and hair growth PH levels

      in Product  36 upvotes 3 years ago
      The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

      community Painkillers May Block Minoxidil

      in Research/Science  15 upvotes 5 months ago
      Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

    Related Research

    6 / 6 results