Growth Factors in Hair Organ Development and the Hair Growth Cycle
October 1996
in “
Dermatologic Clinics
”
growth factors hair follicle development hair growth cycle epithelium mesenchyme EGF FGF TGF-ß IGF PDGF NGF HGF/SF VEGF TGF-α amphiregulin KGF BMPs alopecia transgenic mouse models FGF-5 EGF receptor epithelial cells mesenchymal cells epidermal growth factor fibroblast growth factor transforming growth factor-beta insulin-like growth factor platelet-derived growth factor nerve growth factor hepatocyte growth factor/scatter factor vascular endothelial growth factor transforming growth factor-alpha keratinocyte growth factor bone morphogenetic proteins hair loss genetically modified mouse models fibroblast growth factor-5 epidermal growth factor receptor
TLDR Growth factors are crucial for hair development and could help treat hair diseases.
The document from 1996 reviews the importance of growth factors in hair follicle development and the hair growth cycle. It explains that these processes are complex and rely on interactions between cells in the epithelium and mesenchyme, with growth factors playing a crucial role. The review details the involvement of various growth factor families, such as EGF, FGF, TGF-ß, IGF, PDGF, NGF, HGF/SF, and VEGF, in hair growth control. It emphasizes the complexity of growth factor interactions and the significance of their receptors in signal transduction. Specific growth factors like TGF-α, amphiregulin, KGF, and BMPs are discussed for their roles in hair development and potential therapeutic implications for alopecia. The document also highlights findings from transgenic mouse models, which illustrate the significant functions of growth factors like FGF-5, TGF-α, and the EGF receptor in hair follicle development. The conclusion suggests that a deeper understanding of growth factors could lead to better treatments for hair-related diseases.
