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Glossary Insulin-like Growth Factor

protein promoting cell growth and development, similar to insulin

Insulin-like Growth Factor (IGF) refers to a group of proteins with a structure similar to insulin that play a crucial role in growth and development, particularly during childhood. IGF is involved in cell growth, differentiation, and survival, and it is primarily produced in the liver in response to growth hormone stimulation. It has significant implications in various biological processes, including muscle growth, bone development, and even hair follicle health.

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Research

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research Role of insulin, insulin‐like growth factor‐1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris

200 citations , August 2009 in “Experimental dermatology”

This article reviews the role of IGF-1 in acne pathogenesis and discusses how diet and smoking may influence insulin/IGF-1 signaling, but reports no new clinical results.

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

173 citations , July 1995 in “Biochemical and biophysical research communications”

This study suggests that IGF-I may mediate androgen-induced hair growth in outer root sheath cells cocultured with beard dermal papilla cells.

research Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice

147 citations , April 1997 in “Oncogene”

This study found that transgenic mice expressing IGF-1 in their skin showed significant skin changes, early hair follicle generation, and a higher propensity to develop tumors after chemical promotion, suggesting IGF-1's role in skin carcinogenesis.

research Insulin-like growth factor 1 and hair growth

98 citations , November 1999 in “Dermatology Online Journal”

This review discusses the effects of IGF-1 on hair follicle cell proliferation and differentiation, highlighting its roles in paracrine signaling, apoptosis prevention, and hair growth, but reports no new clinical results.

research Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet

93 citations , January 2016 in “British Journal of Dermatology”

This study found that patients with acne vulgaris had higher serum IGF-1 levels and more intense FoxO1 and mTOR expression than controls, suggesting their role in acne pathogenesis.

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community Bloodflow? Does it affect hair growth?

23 upvotes 7 years ago

Hair loss is primarily caused by genetic sensitivity to DHT, not lifestyle factors like diet or exercise. Treatments like Minoxidil and Finasteride can help, but it's important to consult a dermatologist to determine the best approach for individual cases.

community Claim: Insulin resistance increases the enzyme that creates DHT and affects the liver's ability to control hormones

in Research/Science 4 upvotes 11 months ago

Insulin resistance may increase DHT production, contributing to hair loss, and addressing it through diet, nutrients, and natural DHT blockers like saw palmetto and pumpkin seed oil could help reverse hair loss. Some users prefer medications like finasteride for more effective results.

community Serum based on plant extracts boosts hair growth in weeks.

44 upvotes 11 months ago

A serum containing Centella asiatica extracellular vesicles, IGF-1, FGF-7, and caffeine significantly improved hair thickness, density, length, and reduced hair loss after 56 days. The conversation also discusses how treatments like finasteride, minoxidil, and ketoconazole address different aspects of hair loss by reducing DHT, improving blood flow, and lowering inflammation.

community Bruteforcing alopecia or the new advent of science progress

22 upvotes 1 year ago

Combining therapies like scyllo-inositol, alpha-ketoglutarate, and autophagy-inducing supplements may enhance hair growth and prevent hair loss. Reporting individual results can accelerate progress in hair loss treatments.

community Ultimate Stack without nuking your gender (you'll go broke)

86 upvotes 1 year ago

A hair loss treatment plan includes finasteride, dutasteride, RU58841, pyrilutamide, minoxidil, and microneedling to inhibit DHT and promote hair growth. It also recommends supplements like Reishi and Lion’s Mane mushrooms, and a shampoo with ketoconazole, caffeine, and melatonin.

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learn Thymosin Beta 4

learn Metformin

Diabetes drug that lowers blood sugar

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