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    Glossary Insulin-like Growth Factor

    protein promoting cell growth and development, similar to insulin

    Insulin-like Growth Factor (IGF) refers to a group of proteins with a structure similar to insulin that play a crucial role in growth and development, particularly during childhood. IGF is involved in cell growth, differentiation, and survival, and it is primarily produced in the liver in response to growth hormone stimulation. It has significant implications in various biological processes, including muscle growth, bone development, and even hair follicle health.

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    1. Role of insulin, insulin‐like growth factor‐1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris Experimental dermatology · 2009 · 200 citations
    2. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995 · 173 citations
    3. Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice Oncogene · 1997 · 147 citations
    4. Insulin-like growth factor 1 and hair growth Dermatology Online Journal · 1999 · 98 citations
    5. Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet British Journal of Dermatology · 2016 · 93 citations
    6. Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles<i>in vitro</i> British Journal of Dermatology · 2014 · 60 citations
    7. The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia Journal of The American Academy of Dermatology · 2003 · 49 citations
    8. Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts**This work was supported by NIDDK Grant DK-45227 and a scholarship (to R.C.P.) from Fundacao Coordenacao de Aperfeicoa mento de Pessoal de Nivel Superior (CAPES), Universidade de Sao Paulo (Sao Paulo, Brazil). Endocrinology · 1999 · 43 citations
    9. Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells PLoS ONE · 2011 · 39 citations
    10. Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans Growth hormone & IGF research · 2008 · 39 citations
    11. Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1 Journal of cellular physiology · 1996 · 37 citations
    12. l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase 2009 · 34 citations
    13. Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-like Growth Factor 1 1999 · 33 citations
    14. Dihydrotestosterone inhibits hair growth in mice by inhibiting insulin-like growth factor-I production in dermal papillae Growth Hormone & IGF Research · 2024 · 32 citations
    15. Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I Disease Markers · 2016 · 29 citations
    16. Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice The Journal of Nutritional Biochemistry · 2011 · 29 citations
    17. Insulin-like growth factor-1: roles in androgenetic alopecia Experimental Dermatology · 2014 · 27 citations
    18. Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3 Journal of The American Academy of Dermatology · 2000 · 26 citations
    19. The localisation and characterisation of insulin-like growth factor-I receptors and the investigation of melatonin receptors on the hair follicles of seasonal and non-seasonal fibre-producing goats 1996 · 26 citations
    20. Promotion of Insulin-Like Growth Factor-I Production by Sensory Neuron Stimulation; Molecular Mechanism(s) and Therapeutic Implications Current medicinal chemistry · 2008 · 23 citations
    21. Icariin promotes mouse hair follicle growth by increasing insulin-like growth factor 1 expression in dermal papillary cells Clinical and Experimental Dermatology · 2017 · 22 citations
    22. Cow placenta extract promotes murine hair growth through enhancing the insulin - like growth factor-1 2011 · 22 citations
    23. Induction of insulin‐like growth factor‐I by cepharanthine from dermal papilla cells: A novel potential pathway for hair growth stimulation The Journal of Dermatology · 2013 · 13 citations
    24. Expression of transforming growth factor-beta (TGF-beta 1) and insulin-like growth factor II (IGF-II) messenger RNA in the developing subcutaneous tissue (SQ) of the fetal pig. PubMed · 1992 · 11 citations
    25. Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia Dermatologic Surgery · 2018 · 10 citations
    26. Inhibition of Insulin-Like Growth Factor-1–Induced Sebum Production by Bilobetin in Cultured Human Sebocytes Annals of Dermatology · 2019 · 8 citations
    27. Both low circulating insulin-like growth factor-1 and high-density lipoprotein cholesterol are associated with hair loss in middle-aged women British Journal of Dermatology · 2016 · 6 citations
    28. Topical tacrolimus suppresses the expression of vascular endothelial growth factor and insulin-like growth factor-1 in late anagen Clinical and Experimental Dermatology · 2009 · 6 citations
    29. Red Deer Antler Extract Accelerates Hair Growth by Stimulating Expression of Insulin-like Growth Factor I in Full-thickness Wound Healing Rat Model Asian-australasian Journal of Animal Sciences · 2012 · 4 citations
    30. Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3 Journal of The American Academy of Dermatology · 2000 · 3 citations