Role of Insulin, Insulin-Like Growth Factor-1, Hyperglycemic Food, and Milk Consumption in the Pathogenesis of Acne Vulgaris
August 2009
in “
Experimental dermatology
”
insulin insulin-like growth factor-1 IGF-1 hyperglycemic foods milk consumption acne vulgaris sebaceous gland lipogenesis androgen synthesis androgen receptor activity metformin thiazolidinediones high glycemic diets epidemiological studies dietary modifications pharmacological interventions high sugar foods milk acne oil production male hormones androgen receptor Glucophage Actos high sugar diets diet changes medications
TLDR Eating high-glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.
The review discussed the role of insulin, IGF-1, hyperglycemic foods, and milk consumption in acne vulgaris pathogenesis, highlighting that IGF-1 and insulin stimulate sebaceous gland lipogenesis and androgen synthesis, crucial for acne development. Increased IGF-1 levels correlated with acne severity and enhanced androgen receptor activity. Metformin and thiazolidinediones improved insulin sensitivity and reduced IGF-1 levels, potentially mitigating acne symptoms. High glycemic diets and milk consumption exacerbated acne by increasing IGF-1 levels. Epidemiological studies showed no acne in populations with low glycemic diets and no dairy consumption. Persistent acne with high IGF-1 levels may indicate increased cancer risk, suggesting dietary modifications and pharmacological interventions could improve acne and reduce cancer risk.
