Role of Insulin Resistance and Diet in Acne
January 2013
in “
Indian Journal of Dermatology, Venereology and Leprology
”
insulin resistance diet acne growth hormone insulin insulin-like growth factor-1 IGF-1 adrenal androgen metabolism gonadal androgen metabolism milk consumption high glycemic load sebaceous lipogenesis cell proliferation syndromes associated with insulin resistance hereditary factors androgens follicular retention hyperkeratosis P. acnes colonization inflammatory signaling regulatory neuropeptides hyperinsulinemia androgenic stimulation androgen synthesis peripheral androgenism IGF1R FGFR2b sebocyte differentiation adrenal androgens gonadal androgens milk sebaceous glands cell growth insulin resistance syndromes genetic factors follicular hyperkeratosis P. acnes inflammation neuropeptides high insulin levels androgen stimulation androgen production androgen effects IGF1 receptor FGFR2b receptor sebocyte development
Studysummary This article discusses the role of growth hormone, insulin, and IGF-1 in acne development and highlights how diet and syndromic evidence support their involvement, but presents no new clinical findings.
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