Clinical and Biological Impact of the Exposome on the Skin

July 2020 in “ Journal of the European Academy of Dermatology and Venereology ”

Thierry Passeron, Jean Krutmann, Mônica Levy Andersen, Rajani Katta, Christos C. Zouboulis

hormones hormonal decline hormone replacement therapy skin aging atopic dermatitis acne rosacea inflammation autoimmune skin diseases HRT

TLDR Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

The document from July 1, 2020, reviews the impact of the exposome on skin health, including the effects of environmental factors like solar radiation, air pollution, hormones, nutrition, and psychological stress. It details how chronic solar exposure can lead to skin aging, cancer, and pigmentary changes, while air pollution contributes to skin aging and diseases such as atopic dermatitis and acne. Hormonal decline with age affects skin aging, and hormone replacement therapy may improve skin functions. Nutrition influences skin through processes like oxidation and inflammation, with healthier diets linked to fewer signs of aging and certain foods exacerbating skin conditions like acne and rosacea. Psychological factors like stress and sleep deprivation can worsen inflammatory and autoimmune skin diseases. The document emphasizes the need for further research to understand the mechanisms by which these factors affect the skin and the importance of interventional studies to evaluate the impact of psychological factors on skin conditions.

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