Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin

    May 2001 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Martin Fritsch, Constantin E. Orfanos, Christos C. Zouboulis
    Studysummary This study found that SZ95 sebocytes and HaCaT keratinocytes exhibit distinct enzyme expressions and activities, implicating their different roles in androgen metabolism and homeostasis in vitro.
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    Research cited in this study 8

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    2. Immunohistochemical Localization of Types 1 and 2 5α-Reductase in Human Scalp British Journal of Dermatology · 1999
    3. Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase Predominates in Human Sebaceous Glands Journal of Investigative Dermatology · 1998
    4. Evidence of Heterogeneity and Quantitative Differences of the Type 1 5α-Reductase Expression in Cultured Human Skin Cells: Evidence of Its Presence in Melanocytes Journal of Investigative Dermatology · 1998
    5. The Human Sebocyte Culture Model Provides New Insights Into Development and Management of Seborrhoea and Acne Dermatology · 1998
    6. Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition The Journal of Steroid Biochemistry and Molecular Biology · 1997
    7. The 5 Alpha-Reductase System and Its Inhibitors Dermatology · 1996
    8. Androgen Metabolism in Hirsute Patients Treated with Cyproterone Acetate Journal of steroid biochemistry/Journal of Steroid Biochemistry · 1984