Androgen Metabolism in Hirsute Patients Treated with Cyproterone Acetate

    March 1984 in “ Journal of steroid biochemistry/Journal of Steroid Biochemistry ”
    Irène Mowszowicz, Françoise Wright, M Vincens, Catherine Rigaud, K Nahoul, Philippe Mavier, S Guillemant, Frédérique Kuttenn, P Mauvais-Jarvis
    TLDR Cyproterone acetate effectively reduced hair growth in hirsute patients by lowering androgen levels and altering androgen metabolism.
    The study investigated the effects of cyproterone acetate (CPA) combined with estradiol on 150 hirsute patients over 6 months to 3 years, showing significant clinical improvement. Plasma testosterone (T) and androstenedione (A) levels decreased significantly, while T glucuronide (TG) and 3α-androstanediol (Adiol) levels remained high. T 5α-reductase activity in pubic skin also decreased. The study measured testosterone production rate (PR) and metabolic clearance rate (MCR) in 7 patients, finding a decrease in PR and an increase in MCR, explaining the plasma T concentration drop and high TG and Adiol excretion. CPA's mechanisms included reducing androgen input to target cells, competing for receptor binding sites, and decreasing androgen-dependent skin 5α-R, enhancing its antiandrogenic effect.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 81 results

      community Extreme regimen and still miniaturized hairs. AGA is just impossible to beat.

      in Insane  35 upvotes 1 year ago
      A user's extreme regimen for hair loss, which includes taking oral and topical medications such as minoxidil, dutasteride, cyproterone acetate and bicalutamide, but still experiencing miniaturization. Suggestions were made to try other treatments such as RU58841 and Pyrilutamide, while also considering mental health treatment and advice on lookmaxxing.

      community Are these all the anti androgen products?

      in Treatment  6 upvotes 1 year ago
      The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

      community 5 months of nuking T, 2 months of minoxidil

      in Transgender  485 upvotes 2 months ago
      The user transitioned from finasteride to Cyproterone and started using Minoxidil, resulting in healthier hair and regrowth. They plan to wean off Minoxidil in a year, depending on regrowth.

      community About your erections on finasteride

      in Finasteride  13 upvotes 7 years ago
      People worrying about hair loss and the effects of Finasteride on erections, which a transgirl has experienced no change from taking it with other medications. The discussion suggests that people should stop worrying so much.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  56 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

    Similar Research

    6 / 1000+ results
      Treatment of Hyperandrogenism in Women

      research Treatment of Hyperandrogenism in Women

      8 citations, January 1996 in “Gynecological Endocrinology”
      Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.
      Androgenic Alopecia in Females: Diagnosis and Treatment

      research Androgenic Alopecia in Females: Diagnosis and Treatment

      14 citations, July 1987 in “Dermatologic Clinics”
      The document concludes that treating female hair loss should target reducing excess androgen and blocking its effects on hair follicles, with the best treatments being hormonal therapy, adrenal suppression, and topical minoxidil.
      Hirsutism in Adolescent Females

      research Hirsutism in Adolescent Females

      13 citations, June 1989 in “Pediatric clinics of North America/˜The œPediatric clinics of North America”
      The conclusion is that young women with excessive hair growth should be quickly tested for hormonal issues and treated to improve their social well-being.
      Androgen Antagonists in Androgen Target Tissues

      research Androgen Antagonists in Androgen Target Tissues

      27 citations, January 1984 in “Pharmacology & Therapeutics”
      Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.