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Glossary Androgen-Dependent

biological process influenced by male sex hormones

Androgen-dependent refers to biological processes or conditions that are influenced or regulated by androgens, which are male sex hormones like testosterone. For example, androgen-dependent hair loss, also known as androgenetic alopecia, occurs when hair follicles shrink due to the effects of these hormones, leading to thinning hair or baldness. This term is crucial in understanding conditions that are influenced by hormonal changes, particularly in the context of hair growth and loss.

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Research

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research Evaluation of androgen-dependent skin findings of polycystic ovary syndrome (PCOS)

1 citations , December 2022 in “Gynecological Endocrinology”

This study found that among women with PCOS, higher HOMA-IR levels were associated with acanthosis nigricans, and increased DHEA-SO4, FAI, and FI values were linked to hirsutism.

research ANDROGEN-DEPENDENT DERMOPATHY IN WOMEN WITH KELOID SCARS

January 2019 in “Paëmi Sino”

This study found that acne and androgenic alopecia were prevalent in women with "true" keloids, suggesting hormonal imbalances may contribute to keloid formation.

research A Cationic Ionic Liquid−Liposome Nanoplatform Enables Transdermal asiRNA Delivery for Androgen-Dependent Dermatoses

August 2026 in “ACS Applied Materials & Interfaces”

This study reports that a hybrid nanoplatform using ionic liquid liposomes achieved significant reductions in hair loss, inflammatory acne, and skin sebum levels in preliminary human testing by enhancing delivery of siRNA targeting the androgen receptor.

research Three cases of androgen‐dependent disease associated with myotonic dystrophy

8 citations , January 2003 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

This study describes three female cases of androgen-dependent diseases in myotonic dystrophy, suggesting that peripheral androgen response, rather than serum levels, may drive such conditions.

research Androgen metabolism in hirsute patients treated with cyproterone acetate

64 citations , March 1984 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry”

In this study, cyproterone acetate combined with estradiol dramatically improved hirsutism symptoms and significantly reduced plasma testosterone and androstenedione levels in patients over periods of up to three years.

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Community Join

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community Why are the results so varied depending on WHERE you’re balding??

in Chat 9 upvotes 1 month ago

Minoxidil and finasteride are more effective for diffuse thinning and crown balding because these areas have miniaturizing but still alive hairs that respond well to treatment. The hairline is less responsive to these medications due to its androgen sensitivity and often requires a transplant for restoration.

community DHT Itch is real. The connection between Acne and Male Pattern Baldness shows this

in Research/Science 64 upvotes 3 years ago

The conversation discusses the link between seborrheic dermatitis, acne, and male pattern baldness, suggesting that DHT may cause both skin conditions and hair loss. Treatments mentioned include RU58841, finasteride, dutasteride, minoxidil, Nizoral shampoo, and other topical anti-androgens.

community Ultimate DHT/finasteride microdosing graph to replace the commonly one referenced on forums

202 upvotes 5 years ago

Hair loss treatments, specifically, discussing the effectiveness and side effects of finasteride, minoxidil, and RU58841 in various microdoses. It also includes an updated graph which provides information on how different doses affect DHT levels, scalp skin and serum androgen levels, as well as hair count.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community If RU58841 is such an effective anti androgen

in Research/Science 46 upvotes 2 years ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

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Learn

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learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Epidermal Growth Factor

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

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