research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases
This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.
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5 / 1000+ resultsresearch Structure of human type II 5 alpha-reductase gene.
This article discusses the structure of the human type II 5 alpha-reductase gene and reports no new experimental results.
research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase
This research article focuses on nonsteroidal inhibitors of human type I steroid 5-alpha-reductase but reports no new results.
research 5-Alpha Reductase Inhibitors and Erectile Dysfunction: The Connection
This review highlights that sexual dysfunction associated with 5-alpha-reductase inhibitors is recognized in clinical literature, with erectile dysfunction being the most common adverse effect, followed by ejaculatory dysfunction and decreased libido.
research Comparison of Finasteride (Proscar®) and Serenoa repens (Permixon®) in the Inhibition of 5-Alpha Reductase in Healthy Male Volunteers
This study found that finasteride significantly reduced serum dihydrotestosterone levels, confirming its efficacy as a 5a-reductase inhibitor, while Permixon showed no effect in healthy male volunteers.
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5 / 1000+ resultscommunity 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?
Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.
community Which Saw Palmetto is good for blocking 5 alpha reductase, Serenoa repens or Chamaerops humilis?
The conversation is about determining which type of Saw Palmetto, either Chamaerops humilis or Serenoa repens, is effective for inhibiting the 5 alpha reductase enzyme related to hair loss. Specific treatments mentioned are Minoxidil, finasteride, and RU58841.
community Does anyone know about the mechanism between creatine and 5-alpha reductase?
Creatine may raise DHT levels, potentially affecting hair loss, but its exact mechanism is unclear. Some users report that finasteride remains effective even when taking creatine.
community Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate.
Beta-sitosterol may inhibit 5-alpha reductase type 2 enzyme, potentially reducing DHT levels and promoting hair growth, similar to finasteride but possibly with fewer side effects. Its effectiveness and side effects compared to other treatments like saw palmetto and finasteride remain uncertain due to limited research.
community 17-alpha-estradiol/Alfatradiol how does it Work for Hair loss?
17-alpha-estradiol may work for hair loss by inhibiting 5-alpha reductase, similar to finasteride. It might lower testosterone in the scalp, reducing DHT conversion.
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7 / 24 results- How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.
- Does metformin help control DHT levels that trigger androgenic alopecia? Small studies have found that metformin lowers circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.
learn Dutasteride
5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride
learn Finasteride
Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
learn Fluridil
learn Metformin
learn Saw Palmetto
Palm-berry extract taken as a supplement
learn Azelaic Acid
Acid used in acne and rosacea creams
learn Rosemary
Herb whose oil is used in hair care
Clinics
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Hair TransplantHair Loss TreatmentsAlpha Beauty: Haartransplantation in HannoverHannover, Niedersachsen · DE 
Hair TransplantHair Loss TreatmentsSMPAlpha HaarkliniekAmsterdam · NL- 77
Hair TransplantAlpha Hair RestorationWinter Park, FL · US 
Hair TransplantHair Loss TreatmentsAlpha Keratix hair transplant & facial surgery clinicNagpur, Maharashtra · IN
Hair TransplantHair Loss TreatmentsSMPAlpha Male Cosmetic CenterHouston, TX · US- SMPAlpha Micropigmentation LLCWest Jordan · US
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