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    Azelaic Acid

    Azelaic acid (AzA), or nonanedioic acid, is an organic compound with the formula HOOC(CH2)7COOH. This saturated dicarboxylic acid exists as a white powder. It is found in wheat, rye, and barley. It is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of several hair and skin conditioners. In medicine, topical formulations of AzA are used in the treatment of acne vulgaris, where they exert antimicrobial and keratolytic effects that reduce clogged hair follicles and inflammation. In plants, AzA functions as a mobile signaling molecule that primes systemic acquired resistance against pathogens by inducing the accumulation of salicylic acid. AzA also inhibits tyrosinase.

    Information, not medical advice. Talk to a licensed doctor or pharmacist before starting or changing a treatment.

    Research 10

    1. Efficacy and Safety of Topical 5% Azelaic Acid Solution Versus 2% Minoxidil Solution in the Treatment of Female Pattern Hair Loss Siriraj Medical Journal · 2023
    2. The versatility of azelaic acid in dermatology Journal of Dermatological Treatment · 2020 · 56 citations
    3. Efficacy of topical caffeine in male androgenetic alopecia Journal der Deutschen Dermatologischen Gesellschaft · 2017 · 1 citations
    4. Azelaic Acid: Mechanisms of Action and Clinical Applications Clinical Cosmetic and Investigational Dermatology · 2024 · 34 citations
    5. Eruptive vellus hair cysts in an unusual location with atypical pathological features ˜The œKaohsiung journal of medical sciences · 2018
    6. Comparison of Azelaic Acid and Anthralin for the Therapy of Patchy Alopecia Areata American Journal of Clinical Dermatology · 2005 · 27 citations
    7. Hair Follicle-Targeted Delivery of Azelaic Acid Micro/Nanocrystals Promote the Treatment of Acne Vulgaris International journal of nanomedicine · 2024
    8. Development, Optimization, and In Vitro/In Vivo Evaluation of Azelaic Acid Transethosomal Gel for Antidermatophyte Activity Antibiotics · 2023 · 19 citations
    9. A Study for Verification of Hair Growth Effect of Azelaic Acid and Vitamin B 6 2008
    10. Azelaic Acid in the Treatment of Acne in Adult Females: Case Reports Skin Pharmacology and Physiology · 2013 · 11 citations
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    Community 10

    1. Azelaic acid with ru58841 combination Reddit · 2 Feb 2026
    2. Side effects of topical azelaic acid? Reddit · 29 Mar 2021
    3. How to make Azelaic acid solution from powder? Reddit · 31 Jan 2026
    4. Apparently azelaic acid inhibits DHT, what are the side effects? Reddit · 2 Apr 2021
    5. using Minoxidil 5%+Tretinonin+Azelaic acid topical solution for past 2 months. how's the progress? Reddit · 16 Jul 2024
    6. Switched to a once per day 7% min, 0.15% fin product. Is this a good idea? I'm a week and a half in and second guessing myself. No side effects. Reddit · 10 Sept 2024
    7. Can I Use Topical Azelaic Acid & Oral Finasteride At The Same Time? Reddit · 29 Mar 2024
    8. Male Age 28. On minoxidil 5%+ tretinoin+ azelaic acid topical solution. That's my current situation. Am i cooked? Reddit · 10 Mar 2025
    9. Topical Azelaic acid efficacy? Reddit · 29 Aug 2023
    10. Theoretically won't this be better than finasteride? Azelaic acid + zinc Reddit · 29 Jun 2023
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