BCL-2 and Bax Expression in Skin Flaps Treated with Finasteride or Azelaic Acid

    January 2012 in “ PubMed ”
    Seyyed Mohammad Taghi Ayatollahi, Marjan Ajami, Hamed Reyhanfard, Yasin Asadi, Mansour Nassiri-Kashani, Mehdi Dehghani Firoozabadi, Sayed Hossein Davoodi, Esmaeil Habibi, Hamidreza Pazoki-Toroudi
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    TLDR Azelaic acid and finasteride can help preserve skin flaps after surgery by increasing BCL-2 protein and decreasing bax protein.
    In a study conducted in 2012, researchers evaluated the effect of azelaic acid 20% and finasteride on the expression of BCL-2 and bax proteins after skin flap surgery in 21 rats. The results showed that both azelaic acid and finasteride increased the expression of BCL-2 protein and decreased the expression of bax protein. This suggests that both substances have an antiapoptotic role, potentially helping to preserve the skin flap after the ischemia reperfusion insult, which is a common issue in reconstructive surgeries.
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