TLDR Short-term finasteride treatment may lower some cell death factors in prostate cancer cells.
The 2009 study investigated the impact of short-term finasteride treatment on prostate cancer cells, involving 22 patients who received finasteride and 20 who received a placebo. The treatment, given for at least 30 days before surgery, resulted in a significant decrease in the apoptotic factors caspase-7 and IGFBP-3 in the cancer cells, with no significant effect on other factors like caspase-3, IGF-1, bcl-2, p53, and p21, or on androgen receptor expression. The study concluded that finasteride may reduce certain apoptotic factors in cancer cells, but the implications of these findings for long-term treatment and their relevance to the Prostate Cancer Prevention Trial require further investigation due to the study's short duration and small sample size.
23 citations,
January 2002 in “Journal of Cutaneous Medicine and Surgery” Finasteride helps hair growth by decreasing cell death in hair follicles.
1054 citations,
February 1998 in “The New England Journal of Medicine” Finasteride reduces urinary issues and surgery need in men with enlarged prostates by over 50%.
42 citations,
February 1998 in “The Journal of Steroid Biochemistry and Molecular Biology” PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.
31 citations,
August 2021 in “Stem Cell Research & Therapy” The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
76 citations,
August 2018 in “International Journal of Cosmetic Science” Dermal Papilla cells are a promising tool for evaluating hair growth treatments.
8 citations,
October 2022 in “Regenerative Therapy” New regenerative treatments for hair loss show promise but need more research for confirmation.
70 citations,
February 2015 in “Expert Opinion on Drug Discovery” Topical drugs and near-infrared light therapy show potential for treating alopecia.
June 2023 in “Stem cell reviews and reports” Stem cell therapies could be a promising alternative for hair loss treatment, but more research is needed to understand their full potential and safety.
