TLDR PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.
PNU 157706 was identified as a potent inhibitor of both type I and II 5α-reductase enzymes, surpassing the efficacy of finasteride, a known inhibitor. It demonstrated IC50 values of 3.9 nM for type I and 1.8 nM for type II 5α-reductase in human recombinant enzymes. In vivo studies showed that PNU 157706 reduced prostatic DHT levels more effectively than finasteride in rats, without binding to the androgen receptor, indicating no anti-androgen activity. The compound also significantly reduced prostate weight in castrated rats implanted with testosterone, but not in those implanted with DHT, suggesting its action is specific to inhibiting 5α-reductase. These results suggest PNU 157706 could be a more efficient therapy for conditions related to DHT, such as benign prostatic hyperplasia and androgenic alopecia.
7 citations,
August 1996 in “The Journal of Clinical Endocrinology and Metabolism” 
17 citations,
June 1996 in “The Journal of Steroid Biochemistry and Molecular Biology” FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.
21 citations,
August 1994 in “Clinical endocrinology” 5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.
86 citations,
July 1993 in “Drugs” Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.
53 citations,
June 1993 in “Proceedings of the National Academy of Sciences of the United States of America” LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.
1040 citations,
October 1992 in “The New England Journal of Medicine” Finasteride effectively treats BPH but may increase sexual dysfunction risk.
193 citations,
August 1985 in “Endocrinology” Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.
30 citations,
August 1992 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride doesn't affect hormone levels in normal men.
