PNU 157706, A Novel Dual Type I and II 5α-Reductase Inhibitor

    February 1998 in “ The Journal of Steroid Biochemistry and Molecular Biology ”
    E. Di Salle, D. Giudici, A. Radice … Pierre-Marie Martin
    Studysummary This study found that PNU 157706 is a highly potent inhibitor of human 5α-reductase enzymes, showing a stronger and longer-lasting antiprostatic effect in rats compared to finasteride.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on doi.org →
    Discuss this study in the Community →

    Research cited in this study 7

    1. Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men The Journal of Clinical Endocrinology and Metabolism · 1996
    2. FCE 28260, A New 5α-Reductase Inhibitor: In Vitro and In Vivo Effects The Journal of Steroid Biochemistry and Molecular Biology · 1996
    3. 5α-Reductase Inhibitors and Prostatic Disease Clinical endocrinology · 1994
    4. Finasteride Drugs · 1993
    5. LY191704: A Selective, Nonsteroidal Inhibitor of Human Steroid 5 Alpha-Reductase Type 1 Proceedings of the National Academy of Sciences of the United States of America · 1993
    6. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1992
    7. Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human Endocrinology · 1985

    Related research 1

    1. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992